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These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set mic...
Lift the over 60 flaps in this book to discover the answers to questions that every child asks: when, how, where, who, why, which, and what!
This delightful book explores all kinds of questions that young children ask. Lift the flaps to discover who, what, when, where, how, which, and why.
A fun introduction to prehistoric creatures that are not dinosaurs, and why! Everyone knows what a dinosaur is, right? Well, maybe not. Dinosaurs are actually just one type of extinct animal from prehistoric times. So, what sets them apart? Here, readers are introduced to ten prehistoric animals. Each one looks like a dinosaur. But it’s missing at least one key characteristic of all true dinosaurs. Animal by animal, each of those characteristics is added to a growing list, until, by the end of the book, readers know just what makes a dinosaur a dinosaur! A dinosaur by any other name is . . . not a dinosaur, of course!
A beautifully illustrated, geography book full of flaps to lift to find answers questions such as "When can I see a shooting star?", "Where is the tallest waterfall?", and "What are clouds made of?". Over 50 flaps to lift answer who, what, when, why and where questions about the weather and seasons, countries and languages around the world, what the Earth is made of and lots more. With a map of the world showing many of the features mentioned in the book.
A scientific exploration of stress. Adolescents are no strangers to stress. Now they can learn the science behind that sweaty, heart-racing, under-pressure feeling. This book covers the fight-or-flight reaction to danger, how people cope with chronic stress, how trauma can affect the brain, the ways athletes put pressure to work and the surprising treatments scientists have found to manage stress in everyday life. It’s a perfect primer for young people on what normal stress is and isn’t — and how to deal with it either way. Dealing with stress can be tough. Learning the facts about it can make it manageable.
Born in Scotland over 250 years ago, William Playfair was a dreamer who ñsaw the world differently from other people.î Unfortunately, this skill didnÍt easily translate into the fame and fortune he hoped for. In fact, it often got him into trouble with family, friends and bosses. But WillÍs innovative vision did inspire a big idea that would set him apart: he turned numbers into pictures by creating line graphs, bar graphs and pie charts! Numbers as pictures? ThereÍs an idea thatÍs off the charts!
None of us are ever really alone — not with the trillions and trillions of microbes that call our bodies home. Recent scientific research has uncovered just how interdependent our relationships with these tiny “hitchhikers” are, and that lots of them are actually good for us! Filled with intriguing information and just enough yuck factor, kids will be thrilled to discover what a big deal these small “critters” who live in and on their bodies are. No hand sanitizer required!
This book presents a comprehensive toolkit of versatile techniques for studying microglia under different experimental settings along with a brief summary of knowledge, accumulated in microglial research over the last decades. Beginning with recently discovered roles of microglia in health and disease, the volume continues by covering in vitro analyses of microglia, in vivo studies, and “omics” analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microglia: Methods and Protocols serves as a vital guide to these important cells and an inspiration for scientists interested in expanding our knowledge of their role in the nervous system.
The bestselling I Wonder Why series has the answers to all the questions you’ve ever wanted to ask about the natural world, history, space, and more! Why does the wind blow? How big was the largest snowman ever built? Why do animals sometimes fall out of the sky? Learn the answers to these questions and more in I Wonder Why: The Wind Blows, a fascinating question-and-answer book all about the natural world. Award-winning children's writer Anita Ganeri makes learning fun with her accessible and entertaining style, and information is presented in bite-sized nuggets, making it ideal for dipping in and out. Bright illustrations by Marie-Eve Tremblay bring the natural wonders of our planet to life, from erupting volcanoes to hot sandy deserts.