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Germline Stem Cells
This third edition volume expands on the previous editions with new discussion on the latest techniques and model systems used to study germline stem cells. The chapters in this book cover topics such as analysis of the C. elegans germline stem cell pool; live imaging of the Drosophila testis stem cell niche; standardization of single-cell RNA-sequencing analysis workflow to study Drosophila ovary; 3D analysis of the intact mouse ovary; and derivation and primordial germ cell induction of intermediate pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Germline Stem Cells: Methods and Protocols, Third Edition is a valuable resource for all researchers in the germ stem cell community interested in learning more about this developing field.
Virus Protein and Nucleoprotein Complexes
The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there...
The in Vivo ISGylome Links ISG15 to Metabolic Pathways and Autophagy Upon Listeria Monocytogenes Infection
Abstract: ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity. Here, we map the endogenous in vivo ISGylome in the liver following Listeria monocytogenes infection by combining murine models of reduced or enhanced ISGylation with quantitative proteomics. Our method identifies 930 ISG15 sites in 434 proteins and also detects changes in the host ubiquitylome. The ISGylated targets are enriched in proteins which alter cellular metabolic processes, including upstream modulators of the catabolic and antibacterial pathway of autophagy. Computational analysis of substrate structures reveals that a number of ISG15 modifications occur at catalytic sites or dimerization interfaces of enzymes. Finally, we demonstrate that animals and cells with enhanced ISGylation have increased basal and infection-induced autophagy through the modification of mTOR, WIPI2, AMBRA1, and RAB7. Taken together, these findings ascribe a role of ISGylation to temporally reprogram organismal metabolism following infection through direct modification of a subset of enzymes in the liver
Surface-Enhanced Raman Scattering
Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.
Seeing Straight
Seeing Straight introduces students to key concepts in gender and sexuality through the lens of privilege and power. After an accessible overview, the book asks students to examine the privilege inherent in approaching heterosexual and cisgender identities as “normal,” as well as the problems of treating queer gender and sexuality as “abnormal.” Compelling real-life examples illustrate theory and empirical research, revealing phenomena that shape not only students’ own lives, but also their communities, their country, and the field of gender studies itself. The book addresses tough topics like hate, violence, and privilege, and it also considers institutionalized heteronormativity through the military, law, religion, and more. The book ends with a chapter called “It’s Getting Better” that presents evidence for queer hope and courage. Filled with compelling true stories, this book is an ideal introduction to gender and sexuality that encourages students to question their own assumptions.
Badenheim Nineteen-thirty-nine
A tale of Europe in the days just before the war. It tells of a small group of Jewish holiday makers in the resort of Badenheim in the Spring of 1939. Hitler's war looms, but Badenheim and its summer residents go about life as normal."
Leaving the Wild
A thought-provoking and surprising book that explores the ever-evolving relationship between humans and domesticated animals. The domestication of animals changed the course of human history. But what are the consequences for these animals who have abandoned their wild existence in exchange for our care and protection? Domestication has proven to be a wildly successful survival strategy, but this success has not been without its drawbacks. A modern dairy cow’s daily energy output equals that of a Tour de France rider. Feral cats overpopulate urban areas. And our methods of breeding horses and dogs have resulted in debilitating and sometimes lethal genetic diseases. But these problems and more can be addressed, if we have the will and the compassion. Human values and choices determine an animal’s lot in life even before he or she is born. Just as a sculptor’s hands shape clay, so human values shape our animals—for good and or evil. The little-examined, yet omnipresent act of breeding lies at the core of Gavin Ehringer’s eye-opening book.
