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Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain. Key Selling Features: Describes the ontogeny and phenotype of intervertebral disc cells Reviews the role that inflammation plays in disco-genic pain Highlights the types of cells that might be used as sources for treating degenerating intervertebral discs Summarizes current alternative therapies Explores methods for cell delivery into degenerated intervertebral discs
This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.
A finalidade essencial é a publicação de um Código anotado no sentido rigoroso da expressão, isto é, apoiado numa base científica robusta, sem perder de vista o interesse prático que a melhor teoria nunca deve desvalorizar. Antecedendo a parte comentada, é de referir ainda, pelo seu interesse, a abordagem, de enquadramento geral, da evolução histórica de proteção da propriedade industrial numa perspetiva internacional, europeia e nacional. Luís Couto Gonçalves, Professor na Escola de Direito da Universidade do Minho CORRIGENDA Na nota de rodapé no 1719 desta obra, a marca registada “Jeep”, por lapso, consta na parte inicial quando devia ser referida na parte final, onde são indicadas marcas que constituem exemplos ilustrativos de publicidade corretiva efetuada, ao longo do tempo, pelos respetivos titulares.
An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research
The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models
[In this book, the author's] analysis of the effects and causes of capitalist underdevelopment in Latin America present [an] account of ... Latin American history. [The author] shows how foreign companies reaped huge profits through their operations in Latin America. He explains the politics of the Latin American bourgeoisies and their subservience to foreign powers, and how they interacted to create increasingly unequal capitalist societies in Latin America.-Back cover.
Brazil has one of the world’s fastest growing economies and a fascinating history underpinning its evolution. This book presents an analysis of the state’s role in monetary policy, from the latter days of Portuguese rule, to the present day. Based on a variety of unknown archival sources, this study offers an alternative explanation for the rise and fall of Brazilian currencies. Monetary statecraft is a theory that accounts for the open ended, autonomous character of politics, the complex, recursive phases of public policy, and political development in the traditional sense of social inclusion. Unfortunately, there are few precedents for this type of analysis. This book fills this gap by tracing how Brazilian policy makers and observers have sought, experimented with, and reflected on a variety of forms and solutions for monetary policy since 1808. This book will be of interest to economists, financial historians and those interested in the history and economy of Brazil.