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The Molecular Basis of Dementia
This work aims to shed light on the potential causes and pathogenesis of Alzheimer's disease, Lewy body diseases and frontotemporal dementias. The focus on these clinical diseases is complemented by research reports on transgenic mouse models of alpha-synuclein, tau and amyloid accumulation in the brain. The underlying premise of the research reported in this book is that improved understanding of these protein molecules will open novel avenues of treatment and perhaps even prevention of these neurodegenerative diseases. Contributors include academic scientists, scientists in industry and clinical investigators, all committed to transferring the insights gained in basic research to the physician caring for persons with dementia.
The Role of the Mitochondria in Human Aging and Disease
This volume covers vitually every aspect of mitochondrial research and medicine, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage.
The Future of Hormone Therapy
This volume brings together contributions from those whose expertise or clinical practice involves the study or administration of gonadal hormones. Current knowledge of the biology of gonadal hormones is presented, and the question, What gaps in our knowledge need to be addressed through additional research? is explored.
Immunology of Diabetes III
This volume brings together reports from scientists working in the fields of immunology genetics that refer to both human and animal models of diabetes. In addition, developmental and transplantation biologists report on beta cell development and islet transplantation.
The Metabolic Syndrome X
This collection of papers presents a discussion of the linkages between the diseases that contribute to the metabolic syndrome X - insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemias. The topic is approached from many perspectives, and potential treatment is discussed.
Immunology of Diabetes
The papers included here examine all aspects of diabetes immunology, including studies on the genetics, pathogenesis, prediction, prevention and treatment of the disease. A particular emphasis is given to the human model of the disease as well as to advances in the broader fields of immunology and autoimmunity.
The Abdominal Aortic Aneurysm
Clinical and laboratory information on abdominal aortic aneurysms (AAAs) is reviewed in this volume. The focus is on recent developments related to the biochemistry and cellular pathophysiology of matrix destruction associated with the disease.
Behavioral Neurobiology of Birdsong
An overview of findings in the bird song system that have had a major impact on neuroscience research, and have fundamentally altered our concepts of brain function. The 32 papers constitute the proceedings of a conference on The Behavioural Neurobiology of Bird Song, held in New York in 2002.
Neuronal Mechanisms for Generating Locomotor Activity
At this conference, developments in the understanding of the neuronal basis for locomotion in higher vertebrates were presented and discussed. Amongst the developments covered in this report are a number of in vitro spinal cord preparations, which enable researchers to study locomotor pattern generation from cellular and molecular perspectives. The general principles for rhythmic pattern generation as well as avenues for future research are also discussed,
