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Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction
Pulmonary hypertension (PH) is a disorder of the pulmonary vasculature defined by increased mean pulmonary arterial pressure (mPAP) leading to right ventricle (RV) hypertrophy and dysfunction, right-sided heart failure and ultimately death. PH is a common complication of chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) where it is classified as Group 3 PH by the WHO. It can also be associated with cardiovascular conditions such as left-heart disease (classified as Group 2 PH) or appear on its own as pulmonary arterial hypertension (PAH) and classified as Group1 PH. In all of these cases the diagnosis of pulmonary hypertension is strongly associated with increased morbidity and mortality. The focus of this Research Topic is to enhance our understanding of the mechanisms that contribute to the pathophysiology of pulmonary hypertension and right ventricle hypertrophy.
The Effect of VEGF-induced Angiogenesis on the Viability of Microencapsulated Cells in Vivo [microform]
The microencapsulation of cells in a semi-permeable polymer membrane has been investigated for decades as a platform for the cell-based delivery of therapeutic biomolecules. Previous work investigating the delivery of Vascular Endothelial Growth Factor (VEGF) from cells microencapsulated in HEMA-MMA copolymer demonstrated the ability VEGF-secreting capsules to increase local vascularization in a subcutaneous murine angiogenesis model. To determine whether this increased vascularization would enhance the survival of microencapsulated cells in vivo, a quantitative viability assay was developed using the detection of a secreted form of human placental alkaline phosphatase (SEAP) as a surrogate marker for encapsulated cell viability. The analysis of SEAP secretion from capsules implanted with and without VEGF-induced angiogenesis revealed that the increased local vascularization had no measurable effect on cell viability. In a follow-up study, micro-computed tomography was investigated as a means of evaluating the architecture and functional nature of vessels formed in response to VEGF delivery.
Recent Advances in Cardiology: 17
Recent Advances in Cardiology: 17 provides a selection of review articles that present important advances within the field of cardiac medicine. Written by renowned experts and covering topics such as sudden cardiac death in young adults, biomarkers and risk stratification and HIV and coronary disease, Recent Advances in Cardiology: 17 is essential reading for trainees and practising cardiac physicians wanting to remain up to date with the latest developments in this field. 10 chapters summarising important recent advances within the field of cardiology All topics are written in a practical and clinically relevant manner, further enhanced by the ‘key points for clinical practice’ sections at the end of each chapter Provides an effective exam revision tool for cardiology portion of the MRCP(UK) and the Knowledge Based Assessment in cardiology All chapters written by expert authors ensuring authoritative and accurate content Full colour photographs throughout
Nutrition and Integrative Medicine for Clinicians
Mystery illness can be helped, and this book lays the groundwork for it! Can a water-damaged building ruin your health and cause debilitating exhaustion, chronic pain, insomnia, anxiety, obesity and "brain fog?" Could a flood or wet basement make you sick even if it has long dried out? Building on its predecessor, Nutrition and Integrative Medicine for Clinicians: Volume Two is an essential, peer-reviewed resource for practitioners to help patients with various illnesses found in society, including those contracted from water-damaged structures, that can lay the groundwork for a healthy road to recovery. Written by authors at the forefront of their respective fields, this book presents infor...
Pulmonary Circulation
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
Computational Physiology
This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools available to model subcellular and tissue-level physiology across scales and scientific questions. In June through August of 2021, Simula held the seventh annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). The course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. The majority of the school c...
Transforming the Hermeneutic Context
This book presents contemporary analyses of interpretation by some of the most prominent figures in contemporary philosophy and literary criticism. These essays question and transform traditional statements on the aims, methods, and techniques of interpretation. The essays demonstrate how contemporary discussions of interpretation are necessarily sent back to the hermeneutic tradition. Emphasizing the importance of Friedrich Nietzsches influence on the contemporary debates concerning current interpretive practices, this volume traces the differences in interpretive perspectives generated in the writings of Michel Foucault, Eric Blondel, Julia Kristeva, Jacques Derrida, Manfred Frank, Werner Hamacher, and Jean-Luc Nancy. The essays by Foucault, Blondel, Frank, Hamacher, and Nancy appear here for the first time in English.
The Habermas Handbook
Jürgen Habermas is one of the most influential philosophers of our time. His diagnoses of contemporary society and concepts such as the public sphere, communicative rationality, and cosmopolitanism have influenced virtually all academic disciplines, spurred political debates, and shaped intellectual life in Germany and beyond for more than fifty years. In The Habermas Handbook, leading Habermas scholars elucidate his thought, providing essential insight into his key concepts, the breadth of his work, and his influence across politics, law, the social sciences, and public life. This volume offers a comprehensive overview and an in-depth analysis of Habermas’s work in its entirety. After ex...
