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Outcomes in Clinical Trials
The traditional end-points for clinical studies of lung diseases were based on functional parameters. Their value as surrogate markers for disease activity and progression has been increasingly questioned by scientists, carers, regulatory agencies and funding bodies. Novel tools and methods with regard to biomarkers and patient-reported outcomes have made these parameters emerge from their status as interesting secondary end-points and become potential primary outcomes for clinical trials. Nevertheless, their relevance and validity still needs to be proven. This issue of the European Respiratory Monograph describes the current status regarding end-points in all relevant areas of pulmonary medicine.
To the Latest Posterity
"To the Latest Posterity is filled with examples of family registers from museum and private collections, many of them never before published, including early handmade work as well as printed registers that were filled in by hand in the nineteenth century. Bringing the art into the twentieth century and beyond, the Earnests discuss the adoption of the art by the Amish, who continue the practice of illuminated family record keeping today."--Jacket.
Whistleblower
Mike Stratton, a disbarred attorney, recently released from a federal prison, wakes up in jail in Cardiff-by-the-Sea, California, his boyhood hometown, suffering from amnesia and charged with the rape and murder of Diane Lawson. Her half-naked body was found in his Winnebago, parked at a local campground. Stratton is found next to her; unconscious, and with a head and hand injury—his blood alcohol level off the scale. Stratton ́s last memory is arriving unannounced at his Encino home, where he discovered his wife, Shiela, playing house with Gordon Heller—his best friend, former law partner, and a co-participant in the insider-trading scheme that sent Stratton to prison. When C. J. Hager...
Pennsylvania Archives
A collection of documents supplementing the companion series known as "Colonial records," which contain the Minutes of the Provincial council, of the Council of safety, and of the Supreme executive council of Pennsylvania.
History of the Old Cheraws
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
