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Martin Oliva
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Early Modern Humans at the Moravian Gate
The Upper Paleolithic fossils of the Mladec caves, South Moravia, excavated at the end of the 19th century, hold a key position in the current discussion on modern human emergence within Europe and the fate of the Neanderthals. Although undoubtedly early modern humans - recently radio carbon dated to 31.000 years BP - their morphological variability and the presence of archaic features are indicative to some degree of regional Neanderthal ancestry. The beautifully illustrated monograph addresses - for the first time - the complete assemblage of the finds, including the human cranial, post cranial, teeth and jaw fragments of several individuals (most of them stored at the Natural History Museum Vienna) as well as the faunal remains and the archaeological objects. Leading scientists present their results, obtained with innovative techniques such as DNA analysis, 3D-morphometry and isotope analysis, which are of great importance for further discussions on both human evolution and archaeological issues.
Pain Control
This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.
Official Gazette
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Growing Up in the Ice Age
It is estimated that in prehistoric societies children comprised at least forty to sixty-five percent of the population, yet by default, our ancestral landscapes are peopled by adults who hunt, gather, fish, knap tools and make art. But these adults were also parents, grandparents, aunts and uncles (however they would have codified these kin relationships) who had to make space physically, emotionally, intellectually, and cognitively for the infants, children and adolescents around them. The economic, social, and political roles of Paleolithic children are often understudied because they are assumed to be unknowable or negligible. Drawing on the most recent data from the cognitive sciences a...
Innate Immunity and the Eye
The innate immune system comprises the cells and mechanisms that are the first line of defence against infection by other organisms. This book provides a comprehensive synopsis of eye diseases, their immunological mechanisms and the role of the immune cells and mediators. Beginning with an introduction to the role of the innate immune system, the following chapters discuss the different types of immune cells in the eye and their role in the etiopathogenesis of various diseases including glaucoma and age-related macular degeneration. Edited by Manfred Zierhut, recognised expert from the University of Tuebingen Germany, this book is presented in an easy to read format, enabling practitioners to understand even the most sophisticated eye disorders from an immunological perspective. Key points Comprehensive synopsis of the role of the innate immune system in eye diseases Covers different types of immune cells Edited by internationally recognised specialist in Germany
DNA Repair and Cancer
DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.
Bulletin
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