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Accelerating the development of priority formulations for antibiotic use in children
This document summarizes proceedings and outcomes of a technical consultation designed to develop target product profiles for three priority antibiotics for children, azithromycin, amoxicillin clavulanic acid and nitrofurantoin, that took place on 7–9 May 2024 and was followed up with a closing virtual session on 1 October 2024. Target product profiles for azithromycin and nitrofurantoin were developed as a result and are now being promoted for development and manufacturing of age-appropriate formulations.
Virtual workshop on postnatal prophylaxis to reach elimination of HIV vertical transmission
Despite decades of progress in reducing the rates of vertical transmission, children continue to acquire HIV. Options for more effective regimens to prevent HIV infection among infants have been considered and a number of innovative strategies hold promise to substantially transform postnatal prophylaxis so that elimination of HIV vertical transmission can be achieved. This meeting report synthetizes the outcomes of a workshop held in 2021 by IMPAACT and WHO to achieve consensus on the approach to investigating innovative strategies to prevent HIV vertical transmission perinatally and in the postnatal period and establish the next steps for implementing such studies.
Paediatric drug optimization for neglected tropical diseases
Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations i...
Accelerating optimal approval of priority formulations for antibiotic use in children
On 24 March 2023, WHO launched the first-ever list of priority paediatric formulations for antibiotics, addressing critical gaps in age-appropriate treatments for infants and children. This list, developed through WHO’s Paediatric Drug Optimization (PADO) process, identifies antibiotics urgently needing development to treat infections from high-priority pathogens. WHO, leveraging GAP-f and partners like GARDP and PENTA, led a technical consultation that concluded in March 2024 to review regulatory frameworks and streamline clinical research, aiming to accelerate regulatory approvals and ensure equitable access to effective treatments. The outcomes of this meeting are captured in this report, underscoring the collaborative efforts needed to advance essential paediatric formulations, minimize delays, and support globally aligned, evidence-based care for serious infections in children.
Innovative delivery systems for paediatric medicines
Provided in this landscape analysis is an overview of new and emerging dosage forms and formulation technologies that may be beneficial if applied for use in paediatric patients. It covers various routes of administration including oral, rectal, parenteral, transdermal and others. There is also attention given to long-acting formulations that hold clear promise for use in children. Emphasis is placed upon those dosage forms and technologies which could be suitable for use for children in LMICs. There are key considerations when analysing potential application of these technologies to existing and emerging therapeutic needs for children. Some technologies are ready and available to use in an ...
CureAll framework
This framework document is a “how-to” guide for policy-makers and programme managers to effectively implement the CureAll pillars and enablers. It provides justification for action, posits priority interventions and proposes a monitoring framework. Key components needed to establish, scale up and sustain a well-functioning national childhood cancer programme are explained.The scope of this framework document is centrally defined by the programmes, services and policies that support children with cancer in the context of the health system. For the Initiative, children are defined as those aged 19 years or younger. Childhood cancer care requires cross-cutting strategies, such as workforce ...
