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Primary Liver Cancer in Japan
Hepatocellular carcinoma (HCC) is common in the Far East and South Africa, but is rare in the United States and Europe. The vast experience of the East, which has led to marked improvement in the prognosis of patients with HCC, is made available to researchers worldwide in this monograph. The book is based on an enormous amount of data that has been collected and analyzed by the Liver Cancer Study Group of Japan. The data stems from a survey on HCC in Japan since 1965 and contains information from more than 30,000 patients with regard to age distribution, past medical history, diagnostic procedures, frequency of HBV-associated antigens and antibodies, surgical and conservative treatments, gross anatomical and histological features of the tumors, pathology of the noncancerous portions, distant metastasis, and survival rate. This data is a tremendous contribution to our understanding of the epidemiology, pathology, and the latest developments of the molecular biology and clinical problems of primary liver cancer.
Hepatocellular Carcinoma
Hepatocellular carcinoma is one of the most common fatal malignan cies of mankind. Up to a few decades ago it was looked upon as a cancer which aroused mainly academic concern but relatively little clinical interest, because its therapy and prognosis had a most un favorable outlook. Indeed, it was mostly recognized only at autopsy. Recently this pessimism has radically changed and is disappearing to a rapidly accelerating degree. Many of the scientific contributions at this change in outlook are the result of research in the Far East, first, Japan and then gradually extending to its neighbors. The introduction of experimental hepatocarcinogens by Yoshida more than 50 years ago may have been one of the first important steps. Hepatocellular car cinoma shows a characteristic geographical distribution. With the highest incidence in China, Taiwan, Southeast Asia and sub-Saharan Africa, followed by southern and eastern Europe, while generally the incidence is rather low in western and northern Europe and North and South America.
Elements of Controversy
Unforgettable congressional hearings in 1978 revealed that fallout from American nuclear weapons testing in the 1950s had overexposed hundreds of soldiers and other citizens to radiation. Faith in governmental integrity was shaken, and many people have assumed that such overexposure caused great damage. Yet important questions remain--the most controversial being: did the radiation overexposure in fact cause the cancers and birth defects for which it has been blamed? Elements of Controversy is the result of a decade of exhaustive research in AEC documentary records and the full clinical and epidemiological literature on radiation effects. More concerned with uncovering the historical story t...
Liver Cirrhosis Update
Hardbound. Progress in Hepatology 4 - Liver Cirrhosis Update includes the basic and clinical research on liver cirrhosis and its treatment as presented in the 4th Tadao Takahashi Memorial Forum held in Tokyo, Japan in 1997.Liver cirrhosis is the final outcome of virtually all chronic liver diseases. The etiology differs markedly from country to country. For example, in Japan (and probably most countries of East and Southeast Asia) hepatitis B and C are the most common causes while in western countries it is alcohol. In this volume the focus is almost exclusively on those cases due to HBV and/or HCV. Articles are presented on molecular pathology; classification from a pathological perspective; imaging diagnosis; endoscopic treatment and progress in bioartificial liver support among others. The mechanism of hepatocyte injury differs between virus- and alcohol-induced chronic liver diseases. These differences produce pathological, functio
Germfree Research
Germfree Research: Biological Effect of Gnotobiotic Environments is an account of the Proceedings of the Fourth International Symposium on Germfree Research. The volume comprises of 12 sections and 97 chapters. The first two sections serve as introduction to the status of germfree research as an approach to micro-ecology and gnotobiotic technology in clinical medicine. Another aspect discussed in the book deals with nutrition, metabolism, and microbiology. The last section provides a thorough and detailed discussion on gnotobiotic technology. Large part of the book focuses on gnotobiotic environments and its different aspects. Topics discussed include gnotobiotic environment on isolated patients and in dentistry and parasitology, as well as carcinogenesis in and physiological effects of gnotobiotic environments. The book is a very valuable source of information for many students and professionals in the fields of clinical medicine, biology, microbiology, nutritional science, and biochemistry.
