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Kings in All But Name
Kings in All but Name illustrates how Japan was an ethnically diverse state from the fourteenth through the sixteenth centuries, closely bound by trading ties to Korea and China. It reveals new archaeological and textual evidence proving that East Asia had integrated trading networks long before the arrival of European explorers and shows how mining techniques improved and propelled East Asian trade. The story of the Ouchi rulers contradicts the belief that this was a period of warfare and turmoil in Japan, and instead, proves that this was a stable and prosperous trading state where rituals, policies, politics, and economics were interwoven and diverse.
Artificial Intelligence for Disease Diagnosis and Prognosis in Smart Healthcare
Artificial Intelligence (AI) in general and machine learning (ML) and deep learning (DL) in particular and related digital technologies are a couple of fledging paradigms that next-generation healthcare services are sprinting towards. These digital technologies can transform various aspects of healthcare, leveraging advances in computing and communication power. With a new spectrum of business opportunities, AI-powered healthcare services will improve the lives of patients, their families, and societies. However, the application of AI in the healthcare field requires special attention given the direct implication with human life and well-being. Rapid progress in AI leads to the possibility o...
Vectorology for Optogenetics and Chemogenetics
This volume provides an overview of the viral vectors and how they are applied to chemogenetic and optogenetic tools to the study of neural circuits. The chapters in this book are organized into three parts detailing (1) viral vectors, (2) vector modifications and applications, and (3) practical advice for the delivery of viral vectors, verification of injection accuracy, and monitoring of transgene expression. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Vectorology for Optogenetics and Chemogenetics aims to be a useful practical guide to researches to help further their study in this field.
Functional Micro- and Nanosystems
The 4th caesarium brought together world known experts reporting the state-of-the-art of Functional Micro-and Nanosystems. Its purpose was to identify and open up new research directions in this rapidly evolving new area and to discuss the potential with respect to applications in automotive, biochemical and information technology. Thin film technologies are an attractive approach to incorporate functional properties into micro- or nano-systems. The continuing development towards smaller structures is driven by the use of higher driving frequencies and thus smaller wavelengths, the growing integration of different functions, the higher degree of parallelism, and size requirements for the detection of bio-molecules. Hence this new technology opens up new possibilities in terms of high frequency wireless data transmission over long distances, sensors showing high spatial and time resolution and new devices to process biological, optical and electrical signals.
Time in Medieval Japan
This volume takes a new approach to historical articulations of the concept of time by examining symbolic representations and social regulations of time in various social spheres of medieval Japan. In this way it aims to contribute to a more refined philosophy of time as well as to illuminate an important aspect of the cultural history of Japan.
Adult neurogenesis twenty years later: physiological function versus brain repair
The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.
