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Structure and Physics of Viruses
  • Language: en
  • Pages: 911

Structure and Physics of Viruses

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Protein-based Engineered Nanostructures
  • Language: en
  • Pages: 286

Protein-based Engineered Nanostructures

  • Type: Book
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  • Published: 2016-09-27
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  • Publisher: Springer

This book is devoted to the engineering of protein-based nanostructures and nanomaterials. One key challenge in nanobiotechnology is to be able to exploit the natural repertoire of protein structures and functions to build materials with defined properties at the nanoscale using “bottom-up” strategies. This book addresses in an integrated manner all the critical aspects that need to be understood and considered to design the next generation of nano-bio assemblies. The book covers first the fundamentals of the design and features of the protein building blocks and their self-assembly illustrating some of the most relevant examples of nanostructural design. Finally, the book contains a section dedicated to demonstrated applications of these novel bioinspired nanostructures in different fields from hybrid nanomaterials to regenerative medicine. This book provides a comprehensive updated review of this rapidly evolving field.

Physical Virology
  • Language: en
  • Pages: 348

Physical Virology

This book highlights key findings generated during the past years from the main disciplines that constitute Physical Virology, from theoretical physics and simulations to material sciences and vaccines development to structural biology. Each chapter is written by world-class scientists from these areas and is a comprehensive review of where this field stands, as well as the future of Physical Virology. The diversity in the formal training of these scientists results in solving common problems using very distinct approaches, which can produce surprising findings. The multi- and interdisciplinary nature of this field has created a remarkable community that aims at understanding how viruses wor...

Regulation of Gene Expression in Animal Viruses
  • Language: en
  • Pages: 327

Regulation of Gene Expression in Animal Viruses

Viruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the molecular biology of genome replication and gene expression. Whereas viruses use, in general, pathways of macromolecular biosynthesis common to the host cell, they have a cunning ability to adopt unusual mechanisms of gene expression and gene replication, provided these special pathways offer an advantage in competition for cellular resources. Any study of viral gene expression and replication is likely t...

Foot and Mouth Disease
  • Language: en
  • Pages: 484

Foot and Mouth Disease

  • Type: Book
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  • Published: 2019-04-30
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  • Publisher: CRC Press

The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptabl

Virus Variability, Epidemiology and Control
  • Language: en
  • Pages: 369

Virus Variability, Epidemiology and Control

Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how ever, k...

Molecular Evolution of Viruses — Past and Present
  • Language: en
  • Pages: 223

Molecular Evolution of Viruses — Past and Present

The studies presented in this special issue of VIRUS GENES provide information on the two aspects of virus evolution: the ancient evolution of viruses from the time prokaryotic and eukaryotic cells evolved, and the ongoing process of the current molecular evolution of viruses. The studies of many scientists collected in this issue and many more that were published in other scientific journals provide insight into the molecular evolution of viruses as one of nature's mysteries. The use of computer porograms to study the nucleotide sequences of viral genomes, the amino acid compositions of proteins coded by viral genomes, and searches for regulatory mechanisms in viral nucleic acid replication, as well as identities of motifs in proteins of viruses from all families, will provide additional information on the subject. In future issues that will be devoted to this subject, the origin and evolution of RNA and DNA viruses will be further investigated.

Proteins and Proteomics of Leishmania and Trypanosoma
  • Language: en
  • Pages: 387

Proteins and Proteomics of Leishmania and Trypanosoma

This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups aro...

Philosophical Essays
  • Language: en
  • Pages: 936

Philosophical Essays

A collection of personal essays in philosophy of science (physics, especially gravity), philosophy of information and communication technology, current social issues (emotional intelligence, COVID-19 pandemic, eugenics, intelligence), philosophy of art, and logic and philosophy of language. The distinction between falsification and refutation in the demarcation problem of Karl Popper Imre Lakatos - Heuristics and methodological tolerance Isaac Newton on the action at a distance in gravity: With or without God? Causal Loops in Time Travel The singularities as ontological limits of the general relativity Epistemology of Experimental Gravity - Scientific Rationality Philosophy of Blockchain Tec...

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
  • Language: en
  • Pages: 429

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally d...