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The Neurobiology of Multiple Sclerosis
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
Kings of Cocaine
This is the story of the most successful cocaine dealers in the world: Pablo Escobar Gaviria, Jorge Luis Ochoa Vasquez, Carlos Lehder Rivas and Jose Gonzalo Rodriguez Gacha. In the 1980s they controlled more than fifty percent of the cocaine flowing into the United States. The cocaine trade is capitalism on overdrive -- supply meeting demand on exponential levels. Here you'll find the story of how the modern cocaine business started and how it turned a rag tag group of hippies and sociopaths into regal kings as they stumbled from small-time suitcase smuggling to levels of unimaginable sophistication and daring. The $2 billion dollar system eventually became so complex that it required the manipulation of world leaders, corruption of revolutionary movements and the worst kind of violence to protect.
Hyperborder
Roving vigilantes, fear-mongering politicians, hysterical pundits, and the looming shadow of a seven hundred-mile-long fence: the US–Mexican border is one of the most complex and dynamic areas on the planet today. Hyperborder provides the most nuanced portrait yet of this dynamic region. Author Fernando Romero presents a multidisciplinary perspective informed by interviews with numerous academics, researchers, and organizations. Provocatively designed in the style of other kinetic large-scale studies like Rem Koolhaas's Content and Bruce Mau’s Massive Change, Hyperborder is an exhaustively researched report from the front lines of the border debate.
Memoria 2000
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XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019
This book gathers the proceedings of MEDICON 2019 – the XV Mediterranean Conference on Medical and Biological Engineering and Computing – which was held in September 26-28, 2019, in Coimbra, Portugal. A special emphasis has been given to practical findings, techniques and methods, aimed at fostering an effective patient empowerment, i.e. to position the patient at the heart of the health system and encourages them to be actively involved in managing their own healthcare needs. The book reports on research and development in electrical engineering, computing, data science and instrumentation, and on many topics at the interface between those disciplines. It provides academics and professionals with extensive knowledge on cutting-edge techniques and tools for detection, prevention, treatment and management of diseases. A special emphasis is given to effective advances, as well as new directions and challenges towards improving healthcare through holistic patient empowerment.
Legal Knowledge and Information Systems
Like every other walk of modern life, the law has embraced digital technology, and is increasingly reliant on information systems for its efficient functioning. This book presents papers from the 30th International Conference on Legal Knowledge and Information Systems (JURIX 2017), held in Luxembourg City, Luxembourg, in December 2017. In the three decades since they began, the JURIX conferences have been held under the auspices of the Dutch Foundation for Legal Knowledge Based Systems, and have become a fully European conference series which addresses familiar topics and extends known techniques, as well as exploring newer topics such as question answering and the use of data mining and mac...
Multiple Sclerosis: Bench to Bedside
Multiple Sclerosis (MS) is one of the main causes of disability in young adult population. The estimated burden of the disease worldwide is about three million people. The pathogenic mechanism of MS involves both auto immune and degenerative processes. These two mechanisms are thought to determine a combination of events leading to several clinical pattern of disease onset and course. Multiple Sclerosis: Bench to Bedside provides the most up-to-date and concise reviews on the critical issues of multiple sclerosis from around the world. This book is written by leaders and experts in the field of multiple sclerosis research and is divided into easy to read sections. Section I focuses on basic science aspects of Multiple Sclerosis, including potential biomarkers, molecular biology, heat shock proteins, oxidative stress, genetic and epigenetics. Section II focuses on clinical and epidemiological aspects of Multiple Sclerosis, including remyelination therapy, neuroplasticity-based technologies and interventions. This is an important reference book and a must-read for Postgraduate Medical Scholars, Basic Science Researchers and Neurologists in Clinical Practice.
