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RNA Exosome
The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous r...
Adhesion‐GPCRs
Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodops...
The Arsenal
“Dylan Kane leaves James Bond in his dust!” FROM AWARD-WINNING USA TODAY & MULTI-MILLION COPY BESTSELLING AUTHOR J. ROBERT KENNEDY THE BALANCE OF POWER IS ABOUT TO SHIFT. CAN DYLAN KANE STOP IT BEFORE IT'S TOO LATE? When a nearly bankrupt Russia is forced into a corner by an outraged world, abandoned by its traditional allies concerned with economics rather than ideologies, it plays its final card. A card that could relegate it to middle-power status and make one of America’s greatest enemies an unrivaled superpower. CIA Operations Officer Dylan Kane and his team are in a race against time to expose the deal before it’s completed, otherwise the world will never be the same. In The Ar...
Isocyanide Chemistry
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
Regulation of microRNAs
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
A War Made in Russia
In this timely and incisive book, Sergei Medvedev argues that Russia’s war in Ukraine was not merely a whim of Putin’s obsession: rather, it was the result of two decades of authoritarian degradation and post-imperial ressentiment, a culmination of Putin’s regime and of Russia’s entire imperial history. Building on his prize-winning book The Return of the Russian Leviathan, Medvedev argues that it was not only Putin that started this war, but Russia itself, which, by and large, has imagined and embraced it with enthusiasm, seeking to relive its own military glory and colonial past. Also available as an audiobook.
Personnel Economics in Practice
Personnel Economics in Practice, 3rd Edition by Edward Lazear and Michael Gibbs gives readers a rigorous framework for understanding organizational design and the management of employees. Economics has proven to be a powerful approach in the changing study of organizations and human resources by adding rigor and structure and clarifying many important issues. Not only will readers learn and apply ideas from microeconomics, they will also learn principles that will be valuable in their future careers.
Russian Life
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An Introduction to the Russian Novel
In this book, first published in 1943, Janko Lavrin provides an overview of the development of the Russian novel by placing the great Russian novelists – Tolstoy, Dostoevsky, Turgenev, Gorky, Gogol – in relation to their native literature and their social, political and cultural backgrounds. An Introduction to the Russian Novel will appeal particularly to students of Russian literature and culture as well as those interested in the development of the novel in general.
Opera
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