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Antigen Presenting Cells
This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development. Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists.
Talent Development in European Higher Education
This book examines the much-debated question of how to unleash the potential of young people with promising intellectual abilities and motivation. It looks at the increasingly important topic of excellence in education, and the shift in focus towards the provision of programs to support talented students in higher education. It provides a systematic overview of programs for talented students at northern European higher education institutions (HEIs). Starting in the Netherlands, where nearly all HEIs have developed honors programs over the past two decades, the book explores three clusters of countries: the Benelux, the Nordic and the German-speaking countries. For each of these countries, it...
Molecular Dynamics at the Immunological Synapse
The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve...
Functional Relevance of Tetraspanins in the Immune System
Tetraspanins are small (20-50 kDa) integral membrane proteins with four transmembrane domains that have an intrinsic propensity to associate with other membrane proteins and lipids giving rise to the formation of specific tetraspanin-enriched microdomains (TEMs), also referred to as “The tetraspanin web”. In mammals, the tetraspanin family comprises of 33 different members, with the majority of the members being abundantly expressed in almost all cell types, including leukocytes which are responsible for innate and adaptive immunity as well as in other cells that play pivotal roles in immune responses, such as endothelial or stromal cells. Therefore, through the wide range of specific molecular interactions in which they are engaged, tetraspanins influence many processes of up-most relevance in the development, physiology and pathology of the immune system, including the control of immune cell morphology, signaling, adhesion, migration, invasion, fusion, infections and cancer.
Janeway's Immunobiology
Janeway's Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, all students will appreciate the book's clear writing and informative illustrations, and advanced students and working immunologists will appreciate its comprehensive scope and depth. Janeway's I
Catalysis
There is an increasing challenge for chemical industry and research institutions to find cost-efficient and environmentally sound methods of converting natural resources into fuels chemicals and energy. Catalysts are essential to these processes and the Catalysis Specialist Periodical Report series serves to highlight major developments in this area. This series provides systematic and detailed reviews of topics of interest to scientists and engineers in the catalysis field. The coverage includes all major areas of heterogeneous and homogeneous catalysis and also specific applications of catalysis such as NOx control kinetics and experimental techniques such as microcalorimetry. Each chapter...
EXAFS and Near Edge Structure III
This volume contains the Proceedings of the Third International EXAFS Conference, hosted by Stanford University and the Stanford Synchrotron Radiation Laboratory on July 16-20, 1984. The meeting, co-chaired by Professors Arthur Bienenstock and Keith Hodgson, was attended by over 200 scientists representing a wide range of scientific disciplines. The format of the meeting consisted of 51 invited presenta tions and four days of poster sessions. This Proceedings is a compilation of 139 contributions from both invited speakers and authors of contributed posters. The last ten years has seen the rapid maturation of x-ray absorption spectrosco pyas a scientific discipline. The vitality of the field...
Tumor Immunology and Immunotherapy - Cellular Methods Part A
Tumor Immunology and Immunotherapy - Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more.
Personalized Immunotherapy: Advancing processes to extend patient collectives
Cancer Immunotherapy apart from checkpoint inhibitors is a highly personalized medicine that puts the patient's cells in the focus of drug manufacturing and promises outcomes that rarely have been seen in the history of cancer treatment. CAR-T cells can be mentioned here as the key example that has gained FDA and EMA approvals as the first living drugs for the treatment of leukemias and is now under clinical investigation for application in solid tumors as well. Improvements in cellular engineering in combination with advanced sequencing methods have made it possible to discover tumor-mutation-specific T-cell receptors that can be used to redirect effector cells toward the malignant cell pool with high specificity. This approach opens the opportunity to drug driver mutations that are occurring in a group of patients as well as to design unique patient individual treatment regimens.
