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Comparative Toxicogenomics
Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully a...
Insect Genomics
This volume focuses on the latest methods used to sequence, assemble, and analyze insect genomes. The collection of protocols in this book provides an introduction to the workflows and bioinformatics tools available for researchers. The chapters cover a range of useful topics such as determining genome size by flow cytometry; High Molecular Weight DNA extraction; improvements to a genome assembly provided by long-range sequencing approaches; assessments of orthology and single-copy genes at different phylogenetic levels; detecting regulatory regions with FAIRE, RAMPAGE, and computational analysis of cis-regulatory modules in insects; bioinformatics analysis of epigenetic modifications, high-...
Michigan
Year in and year out, the Wolverines have placed championship banner upon banner atop their record collection. The Wolverines have 47 national team championships, 281 Big Ten titles, more than 1,600 first team All-Americans, nearly 1,300 individual Big Ten champions, and the list goes on. While many schools note periods of success, the U-M has made winning a way of life, emerging from the battles victorious more than 10,000 times. This great tradition has been filled with notable names and spectacular performances.
Physiology of the Cladocera
Physiology of the Cladocera, Second Edition, is a much-needed summary of foundational information on these increasingly important model organisms. This unique and valuable review is based on the world's literature, including Russian research not previously widely available, and offers systematically arranged data on the physiology of Cladocera, assisting with explanation of their life and distribution. It features the addition of new sections and a vast amount of new information, such as the latest data on feeding, nutrition, pathological physiology, chemical composition, neurosecretion, and behavior, as well as hormonal regulation, antioxidants, and the biochemical background of effects of ...
North American Amphibians
"The frogs, toads, salamanders, and newts that inhabit North America, numbering nearly 300 species, represent immense variation in form, habitat, distribution and ecology. This volume discusses the diversity of these animals in relation to the historical geography of the North American continent and portrays all of the formally recognized amphibian species to be found in the United States and Canada within a geographical context. Each species is presented with a color photograph, an account of its range, habitat and conservation status, and an up-to-date, full color range map that depicts its known occurrences in relation to the topography of the landscape. This volume reflects the enormous growth in interest about amphibians and increased intensity of scientific research into their biology and distribution that has occurred during the past two decades"--
Microevolution Rate, Pattern, Process
From guppies to Galapagos finches and from adaptive landscapes to haldanes, this compilation of contributed works provides reviews, perspectives, theoretical models, statistical developments, and empirical demonstrations exploring the tempo and mode of microevolution on contemporary to geological time scales. New developments, and reviews, of classic and novel empirical systems demonstrate the strength and diversity of evolutionary processes producing biodiversity within species. Perspectives and theoretical insights expand these empirical observations to explore patterns and mechanisms of microevolution, methods for its quantification, and implications for the evolution of biodiversity on other scales. This diverse assemblage of manuscripts is aimed at professionals, graduate students, and advanced undergraduates who desire a timely synthesis of current knowledge, an illustration of exciting new directions, and a springboard for future investigations in the study of microevolution in the wild.
Mutation, Randomness, and Evolution
What does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, in...
