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The Neurobiological Basis of Memory
This exciting volume offers an up-to-date tour of current trends in the neurobiology of memory while saluting Raymond Kesner's pioneering contributions to the field as a theorist and researcher, teacher and mentor. Starting with his signature chapter introducing the Attribute Model of Memory, the first half of the book focuses on the central role of the hippocampus in processing dimensions of space and time, and branches out to memory system interactions across brain structures. Later chapters apply the attribute model to multiple functions of memory in learning, and to specific neurological contexts, including Huntington's disease, traumatic brain injury, and Fragile X. As a bonus, the book...
Encyclopedia of Psychopharmacology
Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Extinction Learning from a Mechanistic and Systems Perspective
Throughout their lifetime, animals learn to associate stimuli with their consequences. Following memory acquisition and consolidation, circumstances may arise that necessitate that initially learned behaviour is no longer relevant. The ensuing process is called extinction learning and involves a novel and complex learning procedure that involves a large number of neural entities. While the neural fundaments of the initial acquisition are well studied, our understanding of the behavioural and neural basis of extinction is still limited and derives mostly from rodent data acquired through fear conditioning paradigms. Fear conditioning and extinction in rodents is a spectacularly successful par...
Neurobiology of Learning and Memory
The first edition of Neurobiology of Learning and Memory was published in 1998 to rave reviews. As before, this second edition will discuss anatomy, development, systems, and models though the organization and content is substantially changed reflecting advances in the field. Including information from both animal and human studies, this book represents an up-to-date review of the most important concepts associated with the basic mechanism that support learning and memory, theoretical developments, use of computational models, and application to real world problems. The emphasis of each chapter will be the presentation of cutting-edge research on the topic, the development of a theoretical perspective, and providing an outline that will aid a student in understanding the most important concepts presented in the chapter. *New material covers basal ganglia, cerebellum, prefrontal cortex, and fear conditioning*Additional information available on applied issues (i.e., degenerative disease, aging, and enhancement of memory)*Each chapter includes an outline to assist student understanding of challenging concepts*Four-color illustrations throughout
Linking Affect to Action
Keynote address: Revaluing the orbital prefrontal cortex / R.J. Dolan -- Specialized elements of orbitofrontal cortex in primates / H. Barbas -- The orbitofrontal cortex: Novelty, deviation from expectation, and memory / M. Petrides -- Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions / J.L. Price -- Role of orbitofrontal cortex connections in emotion / N.L. Rempel-Clower -- Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex / G.M. Shepherd -- What can an orbitofrontal cortex-endowed animal do with smells? / J.A. Gottfried -- Taste in the medial orbitofrontal cortex of the maca...
Pharmacological Treatment of Alzheimer's Disease
Prominent Alzheimer's investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer's Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.
Brain Cholinergic Mechanisms
Much of our understanding of brain physiology has focused on what one might call, first order processes. These essentially include the primary synaptic mechanisms underlying excitation (mainly glutamate) and inhibition (mainly GABA). Our attention has focused on how the balance of excitation and inhibition regulates the timing, patterns, and extent of information flow across various circuits. A lot less is understood regarding second order processes that sculpt and modify these primary interactions. One such modulatory transmitter in the brain is acetylcholine (ACh). The importance of ACh in modulating various behaviors related to learning, memory, and attention has been recognized over the ...
Mind Thief
Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown. Mind Thief is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading h...
The 21-Day Sugar Detox Daily Guide
The 21-Day Sugar Detox Daily Guide takes you day by day through Diane Sanfilippo’s popular 21-Day Sugar Detox (21DSD) program. This engaging and colorful book was created to give you new insights on how to succeed based on feedback that Diane has received over seven years of running the program. You’ll learn what to expect each day of the Detox, from how your body might be responding to how you might be feeling mentally. Inside you’ll find: • Meal prep tips and tricks to make cooking easier • Motivational moments to keep you going • Journal space to track your experience and progress • More than 50 mouthwatering recipes that won’t leave you feeling deprived • Recommended pr...
