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Molecular Mechanisms of Werner’s Syndrome
During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
Playing with the Bridge Legends
Since winning the world's most prestigious pairs event in his early twenties, with the equally precocious Michael Rosenberg, Barnet Shenkin has continued to build a an impressive bridge career. Over the last 25 years, he has had the opportunity to play with and against some of the best in the world, and in this book he recounts his favourite hands and stories. While much of his early career was based in Scotland and England, Barnet now lives in Florida and is becoming well-known on the US tournament scene. The book comes to a climax with the US team's record-breaking world title win in January 2000, an event which Barnet covered as a journalist.
The Hands of Time
"As the game of bridge enters its ninth decade of existence, it is fascinating to look back at the best and most exciting moments that have occurred at the bridge table. You'll find it all in this collection: the brilliance, the blunders, the amazing triumphs, and the inexplicable falls from grace. The great players of this last century can be found here too, from Culbertson to Kanta, from Reese to Rodwell, from Harrison-Gray to Hamman and Helgemo, as well as the legendary teams like the Dallas Aces and the Italian Blue Team. Open this book anywhere, and we bet you can't put it down!"--Back cover.
Calorie Restriction, Aging and Longevity
Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a ri...
The Bridge Player's Bedside Book
The ultimate collection of bridge stuff, with something for everyone from the beginner to the expert. Humour, mystery, quizzes, history, biography -- it's all here. Over fifty world-class contributors, including Eddie Kantar, Alfred Sheinwold, Ron Klinger, Phillip Alder, Albert Dormer, and many more. Illustrated throughout, including elegant Fougasse cartoons.
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Advances in DNA Repair in Cancer Therapy
A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Sessional Papers of the Dominion of Canada
"Report of the Dominion fishery commission on the fisheries of the province of Ontario, 1893", issued as an addendum to vol. 26, no. 7.
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