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Novel Approaches in Microbiome Analyses and Data Visualization
High-throughput sequencing technologies are widely used to study microbial ecology across species and habitats in order to understand the impacts of microbial communities on host health, metabolism, and the environment. Due to the dynamic nature of microbial communities, longitudinal microbiome analyses play an essential role in these types of investigations. Key questions in microbiome studies aim at identifying specific microbial taxa, enterotypes, genes, or metabolites associated with specific outcomes, as well as potential factors that influence microbial communities. However, the characteristics of microbiome data, such as sparsity and skewedness, combined with the nature of data collec...
Bayesian Inference for Gene Expression and Proteomics
Expert overviews of Bayesian methodology, tools and software for multi-platform high-throughput experimentation.
Nonparametric Bayesian Inference in Biostatistics
As chapters in this book demonstrate, BNP has important uses in clinical sciences and inference for issues like unknown partitions in genomics. Nonparametric Bayesian approaches (BNP) play an ever expanding role in biostatistical inference from use in proteomics to clinical trials. Many research problems involve an abundance of data and require flexible and complex probability models beyond the traditional parametric approaches. As this book's expert contributors show, BNP approaches can be the answer. Survival Analysis, in particular survival regression, has traditionally used BNP, but BNP's potential is now very broad. This applies to important tasks like arrangement of patients into clinically meaningful subpopulations and segmenting the genome into functionally distinct regions. This book is designed to both review and introduce application areas for BNP. While existing books provide theoretical foundations, this book connects theory to practice through engaging examples and research questions. Chapters cover: clinical trials, spatial inference, proteomics, genomics, clustering, survival analysis and ROC curve.
Bayesian Estimation and Inference in Computational Anatomy and Neuroimaging: Methods & Applications
Computational Anatomy (CA) is an emerging discipline aiming to understand anatomy by utilizing a comprehensive set of mathematical tools. CA focuses on providing precise statistical encodings of anatomy with direct application to a broad range of biological and medical settings. During the past two decades, there has been an ever-increasing pace in the development of neuroimaging techniques, delivering in vivo information on the anatomy and physiological signals of different human organs through a variety of imaging modalities such as MRI, x-ray, CT, and PET. These multi-modality medical images provide valuable data for accurate interpretation and estimation of various biological parameters ...
Statistical Methods in Epilepsy
Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike. Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis,...
Statistical Analysis for High-Dimensional Data
This book features research contributions from The Abel Symposium on Statistical Analysis for High Dimensional Data, held in Nyvågar, Lofoten, Norway, in May 2014. The focus of the symposium was on statistical and machine learning methodologies specifically developed for inference in “big data” situations, with particular reference to genomic applications. The contributors, who are among the most prominent researchers on the theory of statistics for high dimensional inference, present new theories and methods, as well as challenging applications and computational solutions. Specific themes include, among others, variable selection and screening, penalised regression, sparsity, thresholding, low dimensional structures, computational challenges, non-convex situations, learning graphical models, sparse covariance and precision matrices, semi- and non-parametric formulations, multiple testing, classification, factor models, clustering, and preselection. Highlighting cutting-edge research and casting light on future research directions, the contributions will benefit graduate students and researchers in computational biology, statistics and the machine learning community.
Studies in Neural Data Science
This volume presents a collection of peer-reviewed contributions arising from StartUp Research: a stimulating research experience in which twenty-eight early-career researchers collaborated with seven senior international professors in order to develop novel statistical methods for complex brain imaging data. During this meeting, which was held on June 25–27, 2017 in Siena (Italy), the research groups focused on recent multimodality imaging datasets measuring brain function and structure, and proposed a wide variety of methods for network analysis, spatial inference, graphical modeling, multiple testing, dynamic inference, data fusion, tensor factorization, object-oriented analysis and others. The results of their studies are gathered here, along with a final contribution by Michele Guindani and Marina Vannucci that opens new research directions in this field. The book offers a valuable resource for all researchers in Data Science and Neuroscience who are interested in the promising intersections of these two fundamental disciplines.
New Frontiers in Bayesian Statistics
This book presents a selection of peer-reviewed contributions to the fifth Bayesian Young Statisticians Meeting, BaYSM 2021, held virtually due to the COVID-19 pandemic on 1-3 September 2021. Despite all the challenges of an online conference, the meeting provided a valuable opportunity for early career researchers, including MSc students, PhD students, and postdocs to connect with the broader Bayesian community. The proceedings highlight many different topics in Bayesian statistics, presenting promising methodological approaches to address important challenges in a variety of applications. The book is intended for a broad audience of people interested in statistics, and provides a series of stimulating contributions on theoretical, methodological, and computational aspects of Bayesian statistics.
Interactional Humor
The central question explored in this volume is: How is humor multimodally produced, perceived, responded to, and negotiated? To this end, it offers a panorama of linguistic research on multimodal and interactional humor, based on different theoretical frameworks, corpora, and methodologies. Humor is considered as an activity that is interactionally achieved, regardless of whether the interaction in which it is embedded is face-to-face, computer-mediated, with a human or a robot, oral or written. The aim is to analyze both the linguistic resources of the participants (such as their lexicon, prosody, gestures, gazes, or smiles) and the semiotic resources that social networks and instant messaging platforms offer them (such as memes, gifs, or emojis).
Bayesian Statistics 8
The Valencia International Meetings on Bayesian Statistics provide the main forum for researchers in Bayesian Statistics. This eighth proceedings offers the reader a wide perspective of the developments in Bayesian statistics over the last four years.
