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The Proteasome in Neurodegeneration
In the last 50 years a wealth of information has allowed us to understand the contribution of various regulatory factors that alter mRNA and protein s- thesis to a variety of physiological and pathological conditions. However, such regulation is only one of many factors that contribute to the levels of a given p- tein. One major factor that has been relatively obscure until recently has been the contribution of protein degradation to the regulation of the steady state level of protein expression and protein function. This rapidly evolving field has made a significant mark on the scientific community, as highlighted by the Award of the Nobel Prize in Chemistry for 2004 to Aaron Ciechanover, A...
The P2X7 Receptor
This detailed volume covers diverse aspects of P2X7 receptor analysis, ranging from its molecular structure to related pharmacological and immunological tools, via its analysis in heterologous expression systems as well as assays using primary cells and whole animal models. After three introductory chapters that focus on its structure, ligands, and physiological functions, the book details the generation of antibody and nanobody tools for P2X7 receptors, provides protocols for the analysis of expressed P2X7 receptors with a focus on their electrophysiological analysis, as well as protocols for the investigation of P2X7 down-stream signaling in immune cells by flow cytometry. Mouse models and...
Bulletin
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Catholic
The purpose of this book is to share with whomever wants to read it, my simple spiritual journey from childhood through today. This is a journey with numerous peaks and valleys, but with no burning bushes, awesome spiritual experiences, or extraordinary miracles. I am a convinced and passionate Catholic who profoundly respects people who have chosen other Christian denominations, non-Christian religions, or no religion at all. They may be close members of my family, relatives or friends. I unconditionally love them and will never destroy a bridge, build a wall or close a gate that unite us; and I expect to be treated the same way. I am no better or worse than anyone else, and my spiritual journey is no different from other people's journey who were in similar circumstances, such as living in a country where an aggressive, official atheism was an integral part of the political structure and later becoming immigrant in another country, learning a new language, adapting to a new way of life and continuing this earthly pilgrimage. In this journey, I have-now as before-the support and companionship of my loving, compassionate and spiritually correct wife.
