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Fallen Angels
Book eleven in the New York Times bestselling series With news of Horus’s treachery spreading across the galaxy, the Great Crusade grinds to a halt as the primarchs and their Legions decide where their loyalty lies – with the Emperor, or with the rebel Warmaster. The Dark Angels, too, face a time of testing, both among the stars and on their home world Caliban. Luther, once Lion El’Jonson’s trusted second-in-command, now languishes as an exile in all but name while his master struggles to thwart the traitors’ advance upon the forge world Diamat. But an ancient evil gathers its strength beneath the surface of Caliban, and the First Legion will soon be thrust into a deadly conflict where all that they know will be cast into doubt.
There Is No Planet B
Feeding the world, climate change, biodiversity, antibiotics, plastics - the list of concerns seems endless. But what is most pressing, what are the knock-on effects of our actions, and what should we do first? Do we all need to become vegetarian? How can we fly in a low-carbon world? Should we frack? How can we take control of technology? Does it all come down to population? And, given the global nature of the challenges we now face, what on Earth can any of us do? Fortunately, Mike Berners-Lee has crunched the numbers and plotted a course of action that is practical and even enjoyable. There is No Planet B maps it out in an accessible and entertaining way, filled with astonishing facts and analysis. For the first time you'll find big-picture perspective on the environmental and economic challenges of the day laid out in one place, and traced through to the underlying roots - questions of how we live and think. This book will shock you, surprise you - and then make you laugh. And you'll find practical and even inspiring ideas for what you can actually do to help humanity thrive on this - our only - planet.
Oral Bioavailability Assessment
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Characterization of Impurities and Degradants Using Mass Spectrometry
The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products. Both general practitioners in pharmaceutical research and specialists in analytical chemistry field will benefit from this book that will detail step-by-step approaches and new strategies to solve challenging problems related to pharmaceutical research.
Sample Preparation in LC-MS Bioanalysis
Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitiv...
Written Out of History
NEW YORK TIMES BESTSELLER! Some of America’s most important founders have been erased from our history books. In the fight to restore the true meaning of the Constitution, their stories must be told. In the earliest days of our nation, a handful of unsung heroes—including women, slaves, and an Iroquois chief—made crucial contributions to our republic. They pioneered the ideas that led to the Bill of Rights, the separation of powers, and the abolition of slavery. Yet, their faces haven’t been printed on our currency or carved into any cliffs. Instead, they were marginalized, silenced, or forgotten—sometimes by an accident of history, sometimes by design. In the thick of the debates ...
The Underworld of the East
Underworld of the East is the remarkable story of James Lee who, starting in 1895, spent 20 years pursuing all the pleasures and dangers that the Far East had to offer. He travelled with an open mind more in common with our modern times and recorded with stunning candour and great insight a world where few of his contemporaries dared to venture and speaks vividly across time to the Twenty-First Century reader.
Our Lost Constitution
The still-unfolding story of America’s Constitution is a history of heroes and villains—the flawed visionaries who inspired and crafted liberty’s safeguards, and the shortsighted opportunists who defied them. Those stories are known by few today. In Our Lost Constitution, Senator Mike Lee tells the dramatic, little-known stories behind six of the Constitution’s most indispensible provisions. He shows their rise. He shows their fall. And he makes vividly clear how nearly every abuse of federal power today is rooted in neglect of this Lost Constitution. For example: • The Origination Clause says that all bills to raise taxes must originate in the House of Representatives, but contemp...
Saving Nine
In this national bestseller praised by Mark Levin and Sean Hannity, a leading conservative senator explains how the left’s partisan push to pack the Supreme Court with liberal justices has fully migrated from the fringes into the mainstream of Democratic politics. It wasn’t long ago that liberal icons, including the late Supreme Court Justice Ruth Bader Ginsburg, were against the idea of overhauling the court for political gain. But now, in the Biden era, more and more powerful Democrats are getting behind the cause, claiming the high court is broken and actively dismantling our democracy. Even Joe Biden—who once called court-packing a “bonehead idea”—gave in to the progressive wing of his party, appointing a committee to examine “reforms” to the court after being sworn in as president. In Saving Nine, Mike Lee, a brilliant legal mind, details the history of the current composition of the Supreme Court and strongly warns against the norm-shattering precedent that would be set by politically motivated attempts to turn the Supreme Court into just another partisan weapon.
Lee Marvin
The first full-length, authoritative, and detailed story of the iconic actor's life to go beyond the Hollywood scandal-sheet reporting of earlier books, this account offers an appreciation for the man and his acting career and the classic films he starred in, painting a portrait of an individual who took great risks in his acting and career. Although Lee Marvin is best known for his icy tough guy roles—such as his chilling titular villain in The ManWho Shot Liberty Valance or the paternal yet brutally realistic platoon leader in The Big Red One—very little is known of his personal life; his family background; his experiences in WWII; his relationship with his father, family, friends, wives; and his ongoing battles with alcoholism, rage, and depression, occasioned by his postwar PTSD. Now, after years of researching and compiling interviews with family members, friends, and colleagues; rare photographs; and illustrative material, Hollywood writer Dwayne Epstein provides a full understanding and appreciation of this acting titan's place in the Hollywood pantheon in spite of his very real and human struggles.
