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RAS Drug Discovery
KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS. - Highlights key structure-based drug design (SBDD) innovations to generate potency and selectivity vs. KRAS - Analyzes medicinal chemistry case histories for seminal contributions to the KRAS field - Provides an overview of in vitro and in vivo methods for drugging KRAS
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Cancer Evolution
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managi...
Scientific Report
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Concepts and Case Studies in Chemical Biology
Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.
Big Law in Latin America and Spain
This book, part of the Stanford Law School research project on the future of the legal profession, thoroughly examines the future of “big law,” defined as the large and mid-size multiservice highly specialized law firms that provide sophisticated, complex and generally costly legal work to multinationals, large and mid-size domestic corporations, and other business clients. By systematically gathering, assessing, and analyzing the best available quantitative and qualitative data on the first tier of the corporate legal services market of Latin America and Spain, and interviewing a broadly representative sample of corporate legal officers, law firm partners, and other stakeholders in each of the countries covered, this book provides a nuanced perspective on changes in “big law” during the last two decades until the present. It also explores the factors that are driving these changes, and the implications for the future of legal profession, legal education and its relationship with the corporate sector and society in general.
Protein Targeting Compounds
This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies fo...
Law in Many Societies
This law and society reader taps a rich and diverse literature to compare and contrast the legal experience of many different cultures and nations. Drawing on a variety of methodological approaches, the selections allow students to evaluate whether there are general patterns that explain how legal systems work (or fail to work) and how these patterns relate to the structural and cultural facts of society. Every country, of course, has its own legal system, and no two systems are the same. But in teaching law and society, texts have focused nearly exclusively on American readings to the neglect of comparative and international work. This reader fills an obvious gap. It recognizes that law is increasingly global and cross-national, and shows how law relates to society in different times and places, the world over.
From Heaven to Earth
Between the late twelfth century and the mid fourteenth, Castile saw a reordering of mental, spiritual, and physical space. Fresh ideas about sin and intercession coincided with new ways of representing the self and emerging perceptions of property as tangible. This radical shift in values or mentalités was most evident among certain social groups, including mercantile elites, affluent farmers, lower nobility, clerics, and literary figures--"middling sorts" whose outlooks and values were fast becoming normative. Drawing on such primary documents as wills, legal codes, land transactions, litigation records, chronicles, and literary works, Teofilo Ruiz documents the transformation in how medi...
