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Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer trea...
Muslim Identity, Print Culture, and the Dravidian Factor in Tamil Nadu
This work is an original attempt to study the influence of print technology on the Muslims of Tamil Nadu and their literature. It is based on the literary works published by the Tamil Muslims from 1835, when restrictions on printing were removed, to 1920 when they participated in the Khilafat movement. By extension, the study of this literature becomes a study of the origin, society, and identity of the Tamil Muslims.
Proceedings of Second International Conference in Mechanical and Energy Technology
This book presents selected peer-reviewed papers from the International Conference on Mechanical and Energy Technologies, which was held on October 28–29, 2021, at Galgotias College of Engineering and Technology, Greater Noida, India. The book reports on the latest developments in the field of mechanical and energy technology in contributions prepared by experts from academia and industry. The broad range of topics covered includes aerodynamics and fluid mechanics, artificial intelligence, nonmaterial and nonmanufacturing technologies, rapid manufacturing technologies and prototyping, remanufacturing, renewable energies technologies, metrology and computer-aided inspection, etc. Accordingly, the book offers a valuable resource for researchers in various fields, especially mechanical and industrial engineering, and energy technologies.
Recent Developments in Electronics and Communication Systems
Often, no single field or expert has all the information necessary to solve complex problems, and this is no less true in the fields of electronics and communications systems. Transdisciplinary engineering solutions can address issues arising when a solution is not evident during the initial development stages in the multidisciplinary area. This book presents the proceedings of RDECS-2022, the 1st international conference on Recent Developments in Electronics and Communication Systems, held on 22 and 23 July 2022 at Aditya Engineering College, Surampalem, India. The primary goal of RDECS-2022 was to challenge existing ideas and encourage interaction between academia and industry to promote t...
Advanced Production and Industrial Engineering
Things change rapidly in the field of engineering, and awareness of innovation in production techniques is essential for those working in the field if they are to utilise the best and most appropriate solutions available. This book presents the proceedings of ICAPIE-22, the 7th International Conference on Advanced Production and Industrial Engineering, held on 11 and 12 June 2022 in Delhi, India. The aim of the conference was to explore new windows for discoveries in design, materials and manufacturing, which have an important role in all fields of scientific growth, and to provide an arena for the showcasing of advancements and research endeavours from around the world. The 102 peer-reviewed and revised papers in this book include a large number of technical papers with rich content, describing ground-breaking research from various institutes. Covering a wide range of topics and promoting the contribution of production and industrial engineering and technology for a sustainable future, the book will be of interest to all those working in production and industrial engineering.
Enhancing Performance for Action and Perception
This volume of Progess in Brain Research follows on from the 32nd International Symposium of the Groupe de recherche sur le système nerveux central (GRSNC), May 2010, and aims to provide an overview of the various neural mechanisms that contribute to learning new motor and sensory skills, and to adapting to changed circumstances, including the use of devices and implants to substitute for lost sensory or motor abilities (brain machine interfaces). The focus is on recent developments covering five major themes: - Mechanisms to improve motor performance - Neuro-rehabilitation of motor function - Mechanisms to enhance sensory perception - Cross modal interationc for enhancing sensorimotor performance - Assistive technologies to enhance sensorimotor performance - Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Far-Field Optical Nanoscopy
This book describes developments in the field of super-resolution fluorescence microscopy or nanoscopy. In 11 chapters, distinguished scientists and leaders in their respective fields describe different nanoscopy approaches, various labeling technologies, and concrete applications. The topics covered include the principles and applications of the most popular nanoscopy techniques STED and (f)PALM/STORM, along with advances brought about by fluorescent proteins and organic dyes optimized for fluorescence nanoscopy. Furthermore, the photophysics of fluorescent labels is addressed, specifically for improving their photoswitching capabilities. Important applications are also discussed, such as the tracking and counting of molecules to determine acting forces in cells, and quantitative cellular imaging, respectively, as well as the mapping of chemical reaction centers at the nano-scale. The 2014 Chemistry Nobel Prize® was awarded for the ground-breaking developments of super-resolved fluorescence microscopy. In this book, which was co-edited by one of the prize winners, readers will find the most recent developments in this field.
