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Proteopathic Seeds and Neurodegenerative Diseases
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disord...
The Who's Who of Nobel Prize Winners, 1901-2000
The Who's Who of Nobel Prize Winners is a one-stop source of detailed information on the men and women who earned the Nobel Prize during the 20th century. Organized chronologically by prize, each extensive article contains in-depth information on the laureate's life and career as well as a selected list of his or her publications and biographical resources on the individual. A concise commentary explains why the laureate received the award and summarizes the individual's other important achievements. This completely updated edition also contains a history of the prize. Four indexes distinguish this title from similar biographical references and enable researchers to search by name, education, nationality or citizenship, and religion.
Original Intentions
Believing that everything has a precedent, Chinese artists were never bashful about reproducing art, typically seeing less of a difference between the original work and reproductions. As a result, replication has often been considered a fundamental mode of production in Chinese art, with roots extending to antiquity. In turn, some collectors would knowingly brandish originals next to replicas while others completely rejected the idea of imitations as artworks. This book explores the controversial questions of faking, copying, and replicating Chinese painting, bronzes, ceramics, works on paper, and sculpture.
Hurricane Risk
This book details the outcomes of new research focusing on climate risk related to hurricanes. Topics include numerical simulation of tropical cyclones, through tropical cyclone hazard estimation to damage estimates and their implications for commercial risk. Inspired by the 6th International Summit on Hurricanes and Climate Change: From Hazard to Impact, this book brings together leading international academics and researchers, and provides a source reference for both risk managers and climate scientists for research on the interface between tropical cyclones, climate and risk.
Computational Models for Neuroscience
Formal study of neuroscience (broadly defined) has been underway for millennia. For example, writing 2,350 years ago, Aristotle! asserted that association - of which he defined three specific varieties - lies at the center of human cognition. Over the past two centuries, the simultaneous rapid advancements of technology and (conse quently) per capita economic output have fueled an exponentially increasing effort in neuroscience research. Today, thanks to the accumulated efforts of hundreds of thousands of scientists, we possess an enormous body of knowledge about the mind and brain. Unfortunately, much of this knowledge is in the form of isolated factoids. In terms of "big picture" understan...
The International Brigades
Shows just how far ordinary people will go to save democracy against overwhelming odds in a tale of European solidarity that resonates just as strongly today.
Foundations of Cyclopean Perception
A classic and definitive work on cyclopean perception that has influenced vision researchers, cognitive scientists, neuroscientists, artists, designers, and computer graphics pioneers traces the information flow in the visual system.
Practical Electrophysiology
About: Detailed discussion of the fundamental aspects of electrophysiology and includes over 70 case studies from an internationally recognzed group of contributors covering ECGs, SVTs, atrial fibrillation, ventricular tachycardia and more. Includes major contributions from Samuel Asirvatham, MD and Hein J. Wellens, MD. From the Preface: A plethora of significant new research and findings makes it difficult to keep up with the ever-changing field of electrophysiology. Despite these constant advances, there are fundamental aspects of the science that need to be understood by students of electrophysiology. This book was created to educate and uses cases and questions to keep the reader engaged. Chapter and case topics were chosen so that the information presented is useful for years to come. My associate editors and I are hopeful that this book will prove a useful tool for those interested in the field of electrophysiology. We also are very grateful to all the contributing authors for spending their time and effort to help create this handy but comprehensive and interesting work. Jasbir Sra, Milwaukee
Uncommon Understanding (Classic Edition)
This is a Classic Edition of Dorothy Bishop's award-winning textbook on the development of language comprehension, which has been in print since 1997, and now includes a new introduction from the author. The book won the British Psychological Society book award in 1999, and is now widely seen as a classic in the field of developmental language disorders. Uncommon Understanding provides a comprehensive account of the process of comprehension, from the reception of an acoustic signal, to the interpretation of communicative intentions, and integrates a vast field of research on language acquisition, psycholinguistics and neuropsychology. In the new introduction Dorothy Bishop reflects on the or...
