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NIH Publication
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Chemotherapy
The promise of chemotherapeutic control in the field of oncology seemed, in the beginning, no less bright than it had proven in the field of bacterial disease, and, therefore, its failures were felt all the more. Despite the serendipitous discoveries and inspired insights which tantalized us with striking remissions, or the rare tumors which proved to be fully susceptible to a given agent, in the main, there has been either total failure or a painfully slow acquisition of an armamentarium against a limited number of malignancies. To expect more, however, was the result of ignorance of the malignant cell, for, as has been described in the previous volumes of this series, the exploitable diffe...
Leukemia
Much of the attention presently paid to leukemia is the result of recent progress in understanding and treatment. Chemotherapy of leukemia started in the late 1940s, and combination therapy evolved in the late 1950s. It was at that time that the clonality of leukemia was realized, after the discovery of chromosomal and then biochemical and immunological markers. And now we have the new data on retroviral and cellular oncogenes and the reports on human T -cell lymphoma/ leukemia viruses. Many more steps forward could be enumerated in a field which is so rapidly making the hematological textbooks outdated. In this volume, thirteen in-depth reviews from large multicenter trials in the Federal R...
Differentiation and Neoplasia
There is no commonly accepted mechanism to explain differentiation of either normal or neoplastic cells. Despite this fact, the organizers of the 3 rd International Conference on Differentiation recognized that there is much emerging evidence which supports the view that both normal cells and many cancer cells share common differentiative processes. Accordingly, the organizers perceived that clinical scientists and developmental biologists would greatly benefit by together considering differentiation. In that way, developmental biologists would be apprised of recent insights in cancer cell biology and the physician scientist would be updated on events in developmental biology and both would ...
Cancer in Children
Cancer in Children is the first volume in this new series, sponsored by the DICC, on the treatment of cancer. The editors and authors feel strongly that more standardization is needed on a worldwide basis in cancer therapy. This, of course, is only possible if experts from all countries subscribe to a joint policy of making their treatment designs available to practising oncologists all over the world. Current Treatment of Cancer will discuss all the equipment and methods now in use in cancer therapy. It will cover all types of cancer, thus providing the reader with comprehensive information on cancer manage ment. The appearance of a book on paediatric oncology as the first in the series is intentional: in recent decades there has been a tremendous improvement in the treatment of cancer in children, and there is hope for even further success in this fight. We are convinced that this book and the series it is introducing will help us to make a concerted response to the challenge of cancer.
Tumor Aneuploidy
With contributions by numerous experts
Diseases of the Lymphatic System
This volume presents a practical approach for clinicians who work with patients afflicted with diseases of the lymphoid system and bone marrow. Associated biochemical, hematological, and chromosomal abnormalities, as well as infectious complications, are covered because of their importance in managing patients with lymphatic diseases. In addition, cell kinetics and the classification of lym phocytic lymphomas are included because familiarity with these subjects leads to a better understanding of the physiology of the disease. Radiological techniques that aid the clinician in the diagnosis and management of diseases of the lymphoid tissue are discussed. The explosive interest in patients with...
