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Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Drug Discovery
This book, Drug Discovery Research in Pharmacognosy provides a full picture of research in the area of pharmacognosy with the goal of drug discovery from natural products based on the traditional knowledge or practices. Several plants that have been used as food show their potential as chemopreventive agents and the claims of many medicinal plants used in traditional medicine are now supported by scientific studies. Drug Discovery Research in Pharmacognosy is a promising road map which will help us find medicine for all!
Drug Addiction
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Guión de Prácticas. Farmacología II
En el Laboratorio de Farmacología II se plantea el desarrollo de procedimientos experimentales y actividades en los que, bajo el principio de las "tres erres", se reduzca, se reemplace y se refine el uso de animales de laboratorio para cubrir los objetivos de la enseñanza experimental de la Farmacología.
Functional and Bioactive Properties of Food
This book is a printed edition of the Special Issue "Functional and Bioactive Properties of Food" that was published in Foods
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
Inflammation
This volume presents a broad selection of cutting-edge methods and tools that will enable the reader to investigate the multi-faceted manifestations of inflammation. Inflammation: Methods and Protocols is divided into four sections: the first three sections describe protocols investigating immune-mediated inflammatory disease models affecting barrier organs to the environment; the skin, the lung, and the intestinal and oral mucosa. The fourth section illustrates inflammatory disease models of the brain, joints, and vasculature. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and practical, Inflammation: Methods and Protocols aims to inspire the experienced investigator and the young experimenter alike to disentangle the fascinating process of inflammation.
Evidence-Based Chronic Pain Management
A genuine evidence-based text for optimum pain relief in various chronic conditions Contributes an important advance in the practice of pain management providing the information on which to build more coherent and standardised strategies for relief of patient suffering Answers questions about which are the most effective methods, AND those which are not effective yet continue to be used Includes discussion of the positive and the negative evidence, and addresses the grey areas where evidence is ambivalent Written by the world's leading experts in evidence-based pain management this is a seminal text in the field of pain
Freshwater Fungi
The available literature on freshwater fungi is limited. Over the subsequent years a considerable volume of scientific papers have appeared scattered throughout numerous journals. There is therefore no recent synthesis of the subject and this is the objective of the proposed book. Freshwater habitats are rich in fungi with some 3,000 described species, most of papers focussing on their identification, substrata they grow on and world distribution. However, these fungi play an important role in the freshwater ecosystem, and are primarily involved in the breakdown of leaf litter contributing food for detritus feeders. Our book will bring together a wide range of acclaimed mycologists to review recent developments on the biology and ecology of freshwater fungi, particularly their molecular phylogeny, biodiversity, causative diseases of freshwater amphibians, fishes and invertebrate animals, decomposition of leaf litter, stream pollution and their potential role in bioremediation.
