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This volume is a comprehensive guide to the methodologies used in the study of structural domains of cell nuclei. The text covers chromatin, the karyoskeleton, the soluble domain, and the nucleolus. It details methods that are used to isolate components from these domains and techniques used to assemble and disassemble nuclear elements. There is also coverage of three-dimensional mapping and localization of nuclear processes.Key Features* Provides a practical laboratory guide for studying cell nuclei* Includes comprehensive and easy-to-follow protocols
A unified, up-to-date account of circular data-handling techniques, useful throughout science.
The second volume in the Wiley reference series in Biostatistics. Featuring articles from the prestigious Encyclopedia of Biostatistics, many of which have been fully revised and updated to include recent developments, Biostatistics in Clinical Trials also includes up to 25% newly commissioned material reflecting the latest thinking in: Bayesian methods Benefit/risk assessment Cost-effectiveness Ethics Fraud With exceptional contributions from leading experts in academia, government and industry, Biostatistics in Clinical Trials has been designed to complement existing texts by providing extensive, up-to-date coverage and introducing the reader to the research literature. Offering comprehens...
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Egress is the first book to consider the legacy and work of the writer, cultural critic and cult academic Mark Fisher. Narrated in orbit of his death as experienced by a community of friends and students in 2017, it analyses Fisher’s philosophical trajectory, from his days as a PhD student at the University of Warwick to the development of his unfinished book on Acid Communism. Taking the word “egress” as its starting point—a word used by Fisher in his book The Weird and the Eerie to describe an escape from present circumstances as experiences by the characters in countless examples of weird fiction—Egress consider the politics of death and community in a way that is indebted to Fisher’s own forms of cultural criticism, ruminating on personal experience in the hope of making it productively impersonal.