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Huntington's Disease
Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book,...
Techniques in Genetic Engineering
Although designed for undergraduates with an interest in molecular biology, biotechnology, and bioengineering, this book-Techniques in Genetic Engineering-IS NOT: a laboratory manual; nor is it a textbook on molecular biology or biochemistry. There is some basic information in the appendices about core concepts such as DNA, RNA, protein, genes, and
Neurobiological Basis of Migraine
Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the...
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the grow...
Food Additives and Packaging
This ACS Symposium Series book evolved from the ACS symposium "Food Additives and Packaging" sponsored by the Division of Agricultural and Food Chemistry (AGFD) at the 245th ACS National Meeting & Exposition in New Orleans, LA, April 7-11, 2013. The book helps readers understand the rules and regulations governing the use of food additives and food packaging materials in the U.S. and globally. Furthermore, the book investigates novel materials and applications related to food additives and food packaging materials and explores concerns, issues, and current events in the field. The book particularly highlights global regulations, research, development, applications, and evaluation of food add...
The Tobacco Keeper
First published in Arabic in 2008, The Tobacco Keeper relates the investigation of the life of a celebrated Jewish Iraqi musician who was expelled to Israel in the 1950s. Having returned to Iraq, via Iran, the musician is thrown out as an Israeli spy. Returning for the third time under a forged passport, he is murdered in mysterious circumstances. Arriving in Baghdad's Green Zone during the US-led occupation, a journalist writing a story about the musician's life discovers an underworld of fake identities, mafias and militias. Even among the journalists, there is a secret world of identity games, fake names and ulterior motives.
Color and Appearance in Dentistry
This book presents the state of the art in color science and explains its application to dental structures and materials, using high-quality illustrations to ensure ease of learning. Most people seek a bright smile with a natural appearance. This goal often poses a great clinical challenge for the dentist, and its achievement is dependent on a good knowledge of color science and optical properties relevant to dentistry. Further, if a smile is to be esthetically improved to the patient’s satisfaction, the dentist must be able to extract the best from dental materials and techniques, must understand all aspects of facial harmony, and must communicate effectively with both the patient and lab technicians. All of these aspects are thoroughly explored in the book, with detailed coverage of such topics as visual and instrumental shade matching, color management, and avoidance of complications and pitfalls. Color and Appearance in Dentistry will be of high value to all who are engaged in the daily practice of esthetic dentistry.
Karmik Astroloji ve Ezoterizm Işığında 2022
Astroloji, karakteri ortaya çıkarır. Karakterini değiştirebilen insan, geleceği de değiştirmiş olur. İnsanlığın nereden gelip nereye gittiğini öğrenmek adına en kuvvetli referanslardan biridir astroloji... Doğum haritanızdaki eğilimler, hayatın hangi alanlarına doğru götürülebileceğinizi gösterir size. Bu eğilimler toplum kalıplarına göre olumlu veya olumsuz olabilir. İnsan iradesini kullanarak kadere hükmedebilir. Eğer hayatınızı akışa bırakmaya karar verdiyseniz, doğum haritanızda görünen eğilimler zamanı geldikçe etkilerini gösterir. Siz de buna “kader” dersiniz. Oysa bir devrim yaparak özgür iradenizi kullanmayı tercih edebilir, kaderinizi yazmaya başlayabilirsiniz. “Ne yapalım, kaderimiz buymuş işte!” diyemeyeceğimiz zorlu bir süreçten geçiyor dünya. Ezoterik astrolojinin uyarılarına kulak tıkama lüksüne sahip değiliz. Zorluklarla mücadele etmenin tek yolu, bilgiyi nasıl kullanmak gerektiğini bilmektir. 2022 ile başa çıkmaya hazır mısınız?
Ne İçin Varsan Onun İçin Yaşa
“Tüm muhteşem hikâyeler iki şekilde başlar. Ya bir insan bir yolculuğa çıkar ya da şehre bir yabancı gelir.” -Tolstoy Demirden keskin bir düdük sesi yükseldi o sırada. Ayrılığın ciddiyeti buz gibi sardı bedenimi. Kapılar kapandı sonra... Çantam sağımda, yalnızlık karşımda... Gidiyorum! Hayır bir saniye! Filmlerde böyle olmazdı ki... Son anda muhakkak bir kalma sebebi yazardı senarist. Tam hareket etmek üzereyken trenden atlayıverirdi esas adam. Oysa şimdi rayların üzerinde kaymaya başlamıştı bile tren... Ayrılığın göğsüme oturan ağırlığıyla camdan dışarı bakıp el sallayan insanlarla dolu peronu izledim. Beni uğurlamaya gelmeyen herkese teşekkür eder gibi bir damla gözyaşı bıraktım oraya.
Cancer-related Bone Pain
Cancer-related bone pain is experienced by patients with primary bone tumours such as myeloma and osteosarcoma, but is more commonly seen in patients with malignant tumours that have metastasised to bone. Bone pain is one of the most common and severe forms of pain associated with breast, prostate and lung cancer, yet little is known about the underlying mechanisms responsible for the pain. Cancer patients identify bone pain as the most disruptive cancer-related event in terms oftheir quality of life and daily functioning, and it is also associated with increased incidence of morbidity, depression, and anxiety.Part of the Oxford Pain Management Library, this volume summarises the latest evidence-based and practical information on the management of cancer-related bone pain. Chapters cover the pathophysiology and clinical features of bone pain, general principles of management and the use of opioids and other agents. It will be an invaluable reference for all health care professionals involved in the management of patients with bone pain from various disciplines including palliative care,anaesthetics, oncology and general practice.
