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Ts'ao P'i Transcendent
Analyses the foundation of the San-kuo Wei Dynasty by Ts'ao P'I in 220 CE, using the main historical accounts, a wide range of religious and philosophical writings, epigraphical records, and above all, the records contained in the commentaries to Ch'en Shou's San-kuo chih by the fifth century writer P'ei Sung-chih.
Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifier...
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