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This book presents an integrated and holistic discussion on cadmium, lead and mercury toxicity in aquatic environments, expanding general concepts on chemical speciation effects and exploring specific environmental toxicological issues, exposure routes, and bioanalytical approaches for their determination and assessments on their intracellular deleterious effects. It contains worldwide and regional aspects on cadmium, lead and mercury occurrence, fate, and toxicity, addressing key environmental exposure and health risk concerns to both humans and aquatic organisms. Our book is of interest to anyone conducting research in the broad fields of oceanography, geochemistry, ecotoxicology, and environmental and public health.
This handbook of the series Biomarkers in Disease informs comprehensively about all aspects of monitoring and detecting toxicity in the human body and model organisms. Biomarkers for assessing toxicity in diverse organs are presented and different assays and methods are explained. Single compounds and drugs and their toxicity for humans are shown and the methods for detection described. Similar to all the volumes of the Biomarkers in Disease series, the chapters are written by experts in their field, each chapter features key facts summarizing the most important aspects of its respective topic and the definitions of words and terms facilitate the reading and understanding. This handbook is a must-have for researchers in toxicology and biomedicine who analyze the effects of drugs and various other substances in the human body and in model organisms. It also serves as a thorough guide for clinicians and pharmacologists.
This report describes a screening study of in all ninety-nine conventional and emerging per- and polyfluoroalkyl substances (PFASs) in the Nordic environment. In addition, extractable organic fluorine (EOF) was analysed. The latter can provide the amount, but not identity, of organofluorine in the samples, which in turn can be used to assess the mass balance between known and unknown PFASs. The study was initiated by the Nordic Screening Group and funded by these and the Nordic Council of Ministers through the Chemicals Group.A total of 102 samples were analyzed in this study, including bird eggs, fish, marine mammals, terrestrial mammals, surface water, WWTP effluents and sludge, and air. Samples were collected by institutes from the participating countries and self-governing areas; Denmark, Faroe Islands, Finland, Greenland, Iceland, Norway, and Sweden.
Prepared by the Task Committee on the Development of Prestandards for Concentrate Management Case Studies of the Desalination and Water Reuse Technical Committee of the Water, Wastewater, and Stormwater Council of the Environmental and Water Resources Institute of ASCE.Concentrate Management in Desalination: Case Studies, Second Edition, reviews the state-of-the-practice for managing concentrate streams resulting from desalination processes.Concentrate management and disposal in desalination pose environmental and cost concerns--and often determine whether a desalination project is viable, especially for inland communities. This book examines many facets of concentrate management in desalina...
Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology andrequirements of pre-clinical safety assessments of new medicines. with the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. This is an introductory text for students at BSc, MSc and PhD levels,and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug wit
Polymer-based advanced functional materials are one of most sought after products of this global high performance material demand as polymer-based materials guarantee both processing ease and mechanical flexibilities. This volume provides a comprehensive and updated review of major innovations in the field of polymer-based advanced functional materials which focuses on constructive knowledge on advanced multifunctional materials and their resultant techno-commercial applications. The contents aim at restricting the coverage to energy and environment related applications as the said two are the most emerging application domains of polymer-based advanced functional materials. It highlights the...
This publication provides a structured approach to analyzing hazards to groundwater quality, assessing the risk they may cause for a specific supply, setting priorities in addressing these, and developing management strategies for their control. This book summarizes which pathogens and chemicals are relevant to human health, how they are transported, reduced, removed or retarded; provides practical guidance on characterizing the drinking-water catchment area and assessing potential health hazards; provides guidance on prioritising both hazards and management responses; presents key information on potential management actions and explains their integration into a comprehensive Water Safety Plan from catchment to consumer; and describes policy, land-use planning and implementation of pollution prevention, groundwater, with overviews of specific management approaches applicable to agriculture, sanitation, industry, mining, military sites, waste disposal and traffic.--Publisher's description.
Although its early films featured racial caricatures and exclusively Caucasian heroines, Disney has, in recent years, become more multicultural in its filmic fare and its image. From Aladdin and Pocahontas to the Asian American boy Russell in Up, from the first African American princess in The Princess and the Frog to "Spanish-mode" Buzz Lightyear in Toy Story 3, Disney films have come to both mirror and influence our increasingly diverse society. This essay collection gathers recent scholarship on representations of diversity in Disney and Disney/Pixar films, not only exploring race and gender, but also drawing on perspectives from newer areas of study, particularly sexuality/queer studies, critical whiteness studies, masculinity studies and disability studies. Covering a wide array of films, from Disney's early days and "Golden Age" to the Eisner era and current fare, these essays highlight the social impact and cultural significance of the entertainment giant. Instructors considering this book for use in a course may request an examination copy here.
In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.