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Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope
From decades, natural products have been a significant source of health remedies. The use of nature-oriented, bioactive substances in the development of new drugs and traditional medicine is still the priority of the pharmaceuticals. More than 80% to 85% of people throughout the world rely on traditional medicine (TM), as their primary form of healthcare. The easily available TM, mostly herbal products prepared from whole herbs or their extracts, have a significant economic role in many Asian, African, American, and European nations. Therefore, it has become urgent to increase the TM and its constituents' quality, safety, and effectiveness. This can only be accomplished by scientifically validating the lead compounds in TM's chemical foundation and their mode of action. Thanks to the advanced technologies and equipment’s which now has made it easy to create the scaffolds of natural products in the lab, saving a great deal of time as compared to isolating the natural product from its source.
Natural Products Targeting Clinically Relevant Enzymes
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Handbook of Anticancer Drugs from Marine Origin
This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Turn Me Loose White Man
Turn Me Loose White Man is a an examination of virtually all forms of American vernacular music throughout the first 60 years of the twentieth century. It includes a 30 cd set (available separately at www.allenlowe.com) and complete discussion and annotation of over 800 performances in the following genres: Ragtime, minstrelsy, blues, jazz, hillbilly music, country music, blues, rhythm and blues, folk, and rock and roll.
Microcirculation Revisited
The book provides a comprehensive overview of selected topics in microcirculation, from physiology to pathophysiology including molecular mechanisms and clinical aspects. It contains 10 chapters written by reputed authors, which comprehensively sum up the current knowledge and some interesting new insights in the field of microcirculation. It will be useful to a broad range of audience, from students to highly profiled experts, helping them to expand their knowledge on microcirculation and opening up additional questions for further investigation.
A Human Security Doctrine for Europe
Apart from the Study Group's Barcelona Report, it contains fifteen studies especially commissioned by the Study Group to help develop its approach."--Jacket.
Marine and Coastal Ecosystems and Human Well-being
This report is a sysnthesis of the findings of the MA on marine and coastal ecosystems, taken from the global and sub-global assessments. This synthesis report sets out to provide answers to a series of questions that all stakeholders not just decision makers may ask : what is at stake, what is the current status of marine and coastal ecosysytems, why should we care if we lose marine and coastal ecosystems, and what can be done to ensure that marine and coastal ecosystems and services are conserved.
Progress in Standardization of Aquatic Toxicity Tests
Progress in Standardization of Aquatic Toxicity Tests provides a critical evaluation of the level of standardization achieved by freshwater and marine ecotoxicity tests used to evaluate potential risk of new chemicals and wastewater effluents. Tests at the sub-cellular, individual, laboratory microcosm, and ecosystem levels are presented and critically evaluated. The influence of environmental and genetic heterogeneity on test standardization is also discussed. The book will be an excellent reference for industry professionals, consultants, regulatory officials, and students working in the ecotoxicology field.
