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Membrane Transporter Diseases
Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has b...
Genetic Diagnosis of Endocrine Disorders
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
Molecular Genetics and Personalized Medicine
Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.
Writing Gender in Women's Letter Collections of the Italian Renaissance
During the Italian Renaissance, dozens of early modern writers published collections of private correspondence, using them as vehicles for self-presentation, self-promotion, social critique, and religious dissent. Writing Gender in Women's Letter Collections of the Italian Renaissance examines the letter collections of women writers, arguing that these works were a studied performance of pervasive ideas about gender as well as genre, a form of self-fashioning that variously reflected, manipulated, and subverted cultural and literary conventions regarding femininity and masculinity. Meredith K. Ray presents letter collections from authors of diverse backgrounds, including a noblewoman, a courtesan, an actress, a nun, and a male writer who composed letters under female pseudonyms. Ray's study includes extensive new archival research and highlights a widespread interest in women's letter collections during the Italian Renaissance that suggests a deep curiosity about the female experience and a surprising openness to women's participation in this kind of literary production.
Dante
"For all that has been written about the author of the Divine Comedy, Dante Alighieri (1265-1321) remains the best guide to his own life and work. Dante's writings are therefore never far away in this authoritative and comprehensive intellectual biography, which offers a fresh account of the medieval Florentine poet's life and thought before and after his exile in 1302. Beginning with the often violent circumstances of Dante's life, the book examines his successive works as testimony to the course of his passionate humanity: his lyric poetry through to the Vita nova as the great work of his first period; the Convivio, De vulgari eloquentia and the poems of his early years in exile; and the Monarchia and the Commedia as the product of his maturity. Describing as it does a journey of the mind, the book confirms the nature of Dante's undertaking as an exploration of what he himself speaks of as "maturity in the flame of love." The result is an original synthesis of Dante's life and work." --Amazon.com.
A Companion to Pietro Aretino
An interdisciplinary exploration of one of the most prolific and controversial figures of early modern Europe. This volume is comprised of seven sections, each devoted to a specific aspect Aretino’s life and works.
Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases
This updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for clinicians and laboratory personnel alike – reference laboratory data is scattered, and clinical descriptions can be obscure. The new Physician’s Guide with the additional more than 600 diseases now featured, documents 1200 conditions grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). It includes relevant clinical findings and highlights the pathological values for diagnostic metabolites. Guidance on appropriate biochemical genetic testing is also provided and established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book is a valuable desk reference for all who deal with inherited metabolic diseases. Chapter 73 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
Rethinking Gaspara Stampa in the Canon of Renaissance Poetry
Despite the fact that Gaspara Stampa (1523?-1554) has been recognized as one of the greatest and most creative poets and musicians of the Italian Renaissance, scholarship on her work has been surprisingly scarce and uncoordinated. In recent years, critical attention towards her work has increased, but until now there have been no anthologies dedicated solely to Stampa. Rethinking Gaspara Stampa in the Canon of Renaissance Poetry aims to set a foundation for further Stampa studies by accounting for her contributions to literature, music history, gender studies, the history of ideas, philosophy, and other areas of critical thought. This volume brings together an international group of interdis...
The Complete Poems
Gaspara Stampa (1523?-1554) is one of the finest female poets ever to write in Italian. Although she was lauded for her singing during her lifetime, her success and critical reputation as a poet emerged only after her verse was republished in the early eighteenth century. Her poetry runs the gamut of human emotion, ranging from ecstasy over a consummated love affair to despair at its end. While these tormented works and their multiple male addressees have led to speculation that Stampa may have been one of Venice’s famous courtesans, they can also be read as a rebuttal of typical assumptions about women’s roles. Championed by Rainer Maria Rilke, among others, she has more recently been c...
Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also feature...
