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Monitoring Pathophysiology in the Injured Brain
Pathophysiological processes in brain-injured patients can be assessed with an array of methods, with a goal to identify potentially deleterious events, guide treatments and avoid further deterioration. This eBook provides an in-depth exploration into different aspects of neuro-critical care monitoring and how new tools and strategies may be utilized to improve patient outcomes.
Management of Severe Traumatic Brain Injury
This comprehensively updated second edition features major revisions, 24 new chapters and more than 40 new authors, reflecting both the advances and key challenges within the field. Offering a systematic guide to the management of children and adults with severe traumatic brain injury throughout the entire chain of care, it includes evidence-based recommendations for each diagnostic and therapeutic measure, together with tips, tricks and pitfalls. The authors are all highly experienced clinicians and researchers who work with neurotrauma patients on a daily basis, and the editors represent the Scandinavian Neurotrauma Committee. The book helps professionals provide more systematic and higher-quality care in prehospital settings, primary hospitals, neurosurgical departments, neurointensive care units, and rehabilitation facilities. It is intended for all healthcare personnel involved in the multidisciplinary management of patients with head injuries, especially those in emergency care, neurosurgery, anesthesiology, radiology, and rehabilitation.
Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury
Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, manageme...
Neurology and Trauma
Disorders due to trauma to the head, spine, and peripheral nerves are among the most common seen by neurologists and neurosurgeons. This 42 chapter book is the comprehensive, definitive work on the subject, offering coverage on a wide range of clinical issues. The second edition features completely new sections on sports and neurologic trauma and iatrogenic trauma to complement existing comprehensive sections on head trauma, spinal trauma, plexus and peripheral nerve injuries, post-traumatic pain syndromes, environmental trauma, and posttraumatic sequelae and medicolegal aspects. Twenty-two of the first edition's chapters have been revised and updated, eight with new coauthors, and 20 new chapters have been added.
Surgically Treated Intracerebral Haemorrhage
Mortality and morbidity of intracerebral haemorrhage (ICH) is excessively high, and the case fatality rate has not improved in the last decades. Although surgery for ICH can be life-saving, no positive effect on functional outcome has been found in large cohorts of ICH patients. Increased understanding of the pathophysiology of ICH is needed to develop improved treatment strategies. In 17 ICH patients, paired cerebral microdialysis (CMD) catheters were inserted in the perihaemorrhagic zone (PHZ) and in normal uninjured cortex at time of surgery. Despite normalisation of cerebral blood flow, a persistent metabolic crisis indicative of mitochondrial dysfunction was detected in the PHZ. This me...
Rhoton Cranial Anatomy and Surgical Approaches
Rhoton Cranial Anatomy and Surgical Approaches is the masterwork of the legendary neurosurgeon Albert L. Rhoton, Jr.—a distillation of 40 years of work to, in the author’s words, make the “delicate, fateful, and awesome” procedures of neurosurgery more “gentle, accurate, and safe.” This definitive text on the microsurgical anatomy of the brain remains an essential tool for the education and enrichment of neurosurgeons at any level of experience. The hardbound collection of this complete classic work contains more than 2,000 high-quality images.
Excitotoxicity in Neurological Diseases
It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die i...
