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A large body of evidence shows a close link between diabetes and mental health. The spectrum of the diabetes-mental health connection ranges from common determinants to synergistic challenges in management, and to consequent health and quality of life complications and outcomes. One well-documented mental health association with diabetes is depression. Both conditions are prevalent, have been on the rise globally, and are becoming forefront priorities in the context of the COVID-19 pandemic. Current evidence and hypotheses regarding this co-morbidity encompass both physiological processes (namely disruptions in endocrinological, inflammation, and vascular pathways) and psychosocial factors (gender and socioeconomic inequality). Yet, several knowledge gaps remain. A clearer characterization of the building blocks and trajectories underlying the diabetes-depression association is essential for identifying efficacious steps that can help curb this syndemic.
This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies. The aim is both to provide the reader with a sound understanding of the very significant progress that has been achieved in the understanding and management of these malignancies over recent years and to facilitate appropriate choice of the therapeutic strategy in individual cases. The assessment of different prognostic parameters are clearly presented in order to permits effective risk stratification that impacts on treatment choice. Recent insights into lymphomagenesis are exemplified and may assist in identifying emerging therapeutic targets. The comprehensive and up-to-date nature of the book will make it an ideal reference for all physicians and researchers interested in lymphoma, including clinicians from various medical specialties, biologists, pathologists, radiologists and nuclear medicine specialist, as well as students.
Optimal Design of Experiments offers a rare blend of linear algebra, convex analysis, and statistics. The optimal design for statistical experiments is first formulated as a concave matrix optimization problem. Using tools from convex analysis, the problem is solved generally for a wide class of optimality criteria such as D-, A-, or E-optimality. The book then offers a complementary approach that calls for the study of the symmetry properties of the design problem, exploiting such notions as matrix majorization and the Kiefer matrix ordering. The results are illustrated with optimal designs for polynomial fit models, Bayes designs, balanced incomplete block designs, exchangeable designs on the cube, rotatable designs on the sphere, and many other examples.
The interrelations between objects and organisms take many forms, from the microbes known to inhabit medieval manuscripts to the biomorphic forms observable in Art Nouveau lamps, and from the androids cast in American superhero comics to the coral found on Chinese porcelain recovered from shipwrecks. The contributions to this volume investigate various interactions between inanimate and animate matter in art, literature, technology, and other areas of human perception and expression. The book highlights how certain characteristics allow objects to be understood as living organisms, and vice versa. Via a range of dynamics involving vivification and reification, objects and organisms emerge as unstable, transforming within evolving situations. Innovative, interdisciplinary object-scientific contribution to critical ecology From the early modern period into the 21st century
First multi-year cumulation covers six years: 1965-70.
Religion as a form of cultural expression constitutes a critical element in the relationship between Germany and India. The discovery of Indian traditions in Germany and re-interpretations of those traditions in India fueled not only new theological and philosophical explorations, but also extensive innovations in the fields of music, dance, bodily experience, and political intervention. Seeking to uncover the enfolding of colonial thought structures through presentations of the Self, while placing them in the context of global colonial value chains that connected the peripheries with the centre, this interdisciplinary volume addresses India through the lens of an entangled relationship. Ado...
During the period in which Expressionist artists were active in central Europe, art historians were producing texts which also began to be characterized evocatively as ?expressionist?, yet the notion of an expressionist art history has yet to be fully explored in historiographic studies of the discipline. This anthology offers a cross-section of noteworthy art history texts that have been described as expressionist, along with critical commentaries by an international group of scholars. Written between 1912 and 1933, the primary sources have been selected from the published scholarship of both recognized and less-familiar figures in the field's Germanic tradition: Wilhelm Worringer, Fritz Burger, Ernst Heidrich, Max Dvor? Heinrich W?lfflin, and Carl Einstein. Translated here for the first time, these examples of an expressionist turn in art history, along with their secondary analyses and the book's introduction, offer a productive lens through which to re-examine the practice and theory of art history in the early twentieth century.
The definitive text on Hodgkin lymphoma is now in its thoroughly revised, updated Second Edition. More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. This edition describes the increased use of PET scanning in staging and follow-up. Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. Full consideration is given to late effects of therapy and clinical trials for assessing quality of life in patients. This edition includes complete access to the fully searchable online text of the entire book with all the images at www.hodgkinlymphomasolution.com.
Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.