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Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio a...
Trata-se de um estudo monográfico do autor sobre o Prof. Doutor António Augusto da Costa Simões, que foi professor catedrático da Faculdade de Medicina e reitor da Universidade de Coimbra e a personalidade mais rica e de maior vulto que, ao longo dos séculos, nasceu e viveu no concelho da Mealhada e uma das mais resplandecentes, com projeção nacional e internacional, que passaram pela intelectualidade da cidade de Coimbra, que, além de ser palco e feitora da sua formação, foi também a principal beneficiária de toda a sua obra, atividade científica e académica. Este estudo, dedicado ao homem e à obra de Costa Simões, está dividido em seis capítulos: no primeiro, são traçad...
This issue reviews the role of metals in neurodegenerative diseases; including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. - This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease - It reviews the role of metals in neurodegenerative diseases, including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders - An update on advances in neuroimaging and pathology of metal related disease is also presented
This issue of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. - This volume of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve - It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery
O reservado mundo dos negócios e da alta finança, aparentemente bem comportado e elitista, esconde perigosos jogos de poder e sórdidos episódios de mentira, ódio e vingança. A família Espírito Santo, herdeira de uma centenária tradição na banca, dividida há um ano por uma guerra de sucessão, agoniza em rancor e traições: de um lado, Ricardo Salgado, o líder incontestado há mais de 20 anos e hoje o rosto da desgraça que arrastou o nome da família pela lama da falência; do outro, o primo José Maria Ricciardi, que lhe quis tomar o poder e perdeu. Outros nomes milionários protagonizam histórias picantes de poder, ódio e vingança: os Champalimaud, os herdeiros de Horácio Roque e de Tomé Feteira, Joe Berardo, Sousa Cintra, Jardim Gonçalves, os Queiroz Pereira, os Mello...
The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book. This book brings together innovative methodologies and strategies adopted in the research and development...
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This book presents endeavors to join synergies in order to create added value for society, using the latest scientific knowledge to boost technology transfer from academia to industry. It potentiates the foundations for the creation of knowledge- and entrepreneurial cooperation networks involving engineering, innovation, and entrepreneurship stakeholders. The Regional HELIX 2018 conference was organized at the University of Minho’s School of Engineering by the MEtRICs and Algoritmi Research Centers, and took place in Guimarães, Portugal, from June 27th to 29th, 2018. After a rigorous peer-review process, 160 were accepted for publication, covering a wide range of topics, including Control...