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Carl Nielsen and the Idea of Modernism
Beryl Foster's authoritative study can claim to be the most thorough investigation of this repertoire yet to have appeared in English, and is likely to remain the standard work on the subject for many years to come. TLS --
Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA
The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of: History and background Principles and theory Equipment and reagents Protocols Troubleshooting Applications Improvements Results Comparisons with other methods Future prospects and developments This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.
Advances in DNA Sequence-specific Agents
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognit...
In the Hills of Tuscany
This publication present an overview of the author's 20 years of excavation at the Etruscan site of Murlo. Phillips offers his perspective on the site and theories about its functions. The introduction by David and Francesca Ridgway places this important site in the perspective of our current knowledge of the Etruscans. Ingrid Edlund-Berry and the author have compiled an extensive annotated bibliography for the site. This volume will be invaluable to scholars and of interest to anyone intrigued by the mystery of the Etruscans.
Similarity-Based Pattern Recognition
This book constitutes the proceedings of the Second International Workshop on Similarity Based Pattern Analysis and Recognition, SIMBAD 2013, which was held in York, UK, in July 2013. The 18 papers presented were carefully reviewed and selected from 33 submissions. They cover a wide range of problems and perspectives, from supervised to unsupervised learning, from generative to discriminative models, from theoretical issues to real-world practical applications, and offer a timely picture of the state of the art in the field.
Triple Helix Forming Oligonucleotides
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
The Chemical Biology of Nucleic Acids
With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of f...
Biomedical Chemistry
How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, ...
