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Epilepsy Surgery
The thoroughly revised and updated Second Edition of this landmark work is the most comprehensive and current reference on the surgical treatment of the epilepsies. More than 100 invited experts from around the world present a global view of contemporary approaches to presurgical evaluation, surgical treatment, and postsurgical assessment. This edition provides detailed information on the vital role of structural and functional neuroimaging in presurgical evaluation and surgical planning. Noted experts offer up-to-date patient selection guidelines and explain current concepts of intractability. The book details the most effective surgical techniques, presents extensive data on surgical outcome, and discusses strategies for preventing and managing complications. More than 500 illustrations complement the text. An appendix section includes protocols and outcome statistics from over 50 leading epilepsy surgery centers.
Fibrous Proteins: Structures and Mechanisms
This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described ar...
Practical Handbook of Neurosurgery
“Practical Handbook of Neurosurgery” invites readers to take part in a journey through the vast field of neurosurgery, in the company of internationally renowned experts. At a time when the discipline is experiencing a (detrimental) tendency to segment into various subfields and scatter in the process, it can be worthwhile to collect a number of practical lessons gleaned from experienced and leading neurosurgeons. The book also aims to present numerous important figures in the neurosurgical community, with a brief overview of the vitae and main contributions for each. We must confess that we were sad that some of the most active members were unable to participate, likely due to time cons...
Puzzling Cases of Epilepsy
Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the po...
Pediatric Epilepsy
The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies. Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combin...
Protein-Protein Interactions
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Handbook of Epilepsy Treatment
Make your way through the epilepsy maze Epilepsy is a complex neurological condition. There are many modern treatment options, and treatment should nowadays be tailored to an individual patient. But identification of the best therapy can be a labyrinthine process. The Handbook of Epilepsy Treatment provides a practical pathfinder for treating epilepsy based on published evidence and the author’s 30 years of specialist clinical experience. Direct in style but comprehensive in content, with ample tables and summaries, the Handbook of Epilepsy Treatment covers: Treatment of the different forms and causes of epilepsy Treatment in the different commonly encountered clinical situations Treatment...
One Hundred Case Studies in Epilepsy
From pediatric to the elderly, from contractible to refractive, epilepsy is an illness that manifests in many forms and across a range of demographics. In this fascinating volume, the author details more than one hundred instances where health care practitioners faced unusual challenges in treating the disease. All aspects of epilepsy are explored
