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Mitochondrial Oxidative Phosphorylation
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment
Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic ...
Mitochondria in Liver Disease
"...excellent, well-organized, and timely." —Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptib...
The Bubble Act
This book reassesses the actual effects of the Bubble Act, still popularly associated with the bursting of the South Sea Bubble. The book builds on the foundational work of Ron Harris to discuss the act’s effect on corporate governance, literary culture, colonial law, and the Industrial Revolution. The Bubble Act was deemed an empty letter within England itself as it was rarely used in legal proceedings. Several chapters consider whether this was the case outside England, from Scotland to the Americas, India, and Africa. Others assess the impact of the act, both on literary culture and in the history of economic thought. The act has been conceptualized as a brake on economic development or of little consequence. This edited collection offers a timely reassessment of the Bubble Act and its legacy.
Inclusive Physical Activities
Increasing numbers of children and adolescents internationally are being diagnosed with secondary health problems (e.g., overweight-obesity, diabetes, asthma, anxiety, etc.) due in part, or at least related to, a lack of physical activity. Children and adolescents with various forms of special needs (for example, children and adolescents with physical or intellectual disabilities, children and adolescents from disadvantaged social backgrounds and children and adolescents with chronic illnesses) seem to be particularly at risk for secondary health problems, which in the end limit their social participation and inclusion, as well as their ability to achieve their full potential and to lead hap...
Pediatric Solid Organ Transplantation
This book covers all the protocols of pediatric solid organ transplantation in a practical format. It includes detailed protocols of managing a child during pre and post-transplant namely liver, kidney, heart, intestine and pancreas. Chapters include algorithms, figures and protocols in tabulated format. It also provides essential information on anatomy and physiology of relevant topics. The editors and authors are leading experts in the field from across the world. This practical book serves as a useful and step-by-step guide for pediatricians, nephrologists, intensivists and transplant physicians and surgeons.
Annual Report
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Assistive Technology Assessment Handbook
Assistive Technology Assessment Handbook, Second Edition, proposes an international ideal model for the assistive technology assessment process, outlining how this model can be applied in practice to re-conceptualize the phases of an assistive technology delivery system according to the biopsychosocial model of disability. The model provides reference guidelines for evidence-based practice, guiding both public and private centers that wish to compare, evaluate, and improve their ability to match a person with the correct technology model. This second edition also offers a contribution to the Global Cooperation on Assistive Technology (GATE) initiative, whose activities are strongly focused o...
