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Multivariate Statistical Machine Learning Methods for Genomic Prediction
This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.
Generalized Linear Mixed Models with Applications in Agriculture and Biology
This open access book offers an introduction to mixed generalized linear models with applications to the biological sciences, basically approached from an applications perspective, without neglecting the rigor of the theory. For this reason, the theory that supports each of the studied methods is addressed and later - through examples - its application is illustrated. In addition, some of the assumptions and shortcomings of linear statistical models in general are also discussed. An alternative to analyse non-normal distributed response variables is the use of generalized linear models (GLM) to describe the response data with an exponential family distribution that perfectly fits the real re...
Genomic Prediction of Complex Traits
This volume explores the conceptual framework and the practical issues related to genomic prediction of complex traits in human medicine and in animal and plant breeding. The book is organized into five parts. Part One reminds molecular genetics approaches intending to predict phenotypic variations. Part Two presents the principles of genomic prediction of complex traits, and reviews factors that affect its reliability. Part Three describes genomic prediction methods, including machine-learning approaches, accounting for different degree of biological complexity, and reviews the associated computer-packages. Part Four reports on emerging trends such as phenomic prediction and incorporation i...
Introduction to Experimental Designs with PROC GLIMMIX of SAS
In this book, the subject of design and analysis of experiments has been covered in simple language by giving basic concepts of various designs and essential data analysis steps of designed experiments. It has become clear that among researchers, mainly from the areas of food and agricultural sciences, there is a great need for a reference work on design and analysis of experiments that covers basic concepts, provides examples of varied situations that require the use of the experimental designs and that offers clear steps required for the correct analysis execution. This book covers such needs while also sharing codes in the Statistical Analysis Systems (SAS) for each of the designs covered using Proc Glimmix to perform the analysis. It is hoped that this will allow readers to directly analyze the data from their experiments.
Design of Comparative Experiments
This book should be on the shelf of every practising statistician who designs experiments. Good design considers units and treatments first, and then allocates treatments to units. It does not choose from a menu of named designs. This approach requires a notation for units that does not depend on the treatments applied. Most structure on the set of observational units, or on the set of treatments, can be defined by factors. This book develops a coherent framework for thinking about factors and their relationships, including the use of Hasse diagrams. These are used to elucidate structure, calculate degrees of freedom and allocate treatment subspaces to appropriate strata. Based on a one-term course the author has taught since 1989, the book is ideal for advanced undergraduate and beginning graduate courses. Examples, exercises and discussion questions are drawn from a wide range of real applications: from drug development, to agriculture, to manufacturing.
Generalized Linear Models
Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities." —Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Maintaining the same nontechnical approach as its predecessor, this update has been thoroughly exte...
Confessions of an Economic Hit Man
Perkins, a former chief economist at a Boston strategic-consulting firm, confesses he was an "economic hit man" for 10 years, helping U.S. intelligence agencies and multinationals cajole and blackmail foreign leaders into serving U.S. foreign policy and awarding lucrative contracts to American business.
