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With a long practice of organ transplantation, retransplantation has become a major goal in patients with long-term failure of their first transplant (chronic rejection, exhaustion of the transplant, recurrence of initial disease, etc.). In addition, retransplantation can be necessary in the initial period, due to severe acute rejection, non-functioning organ or surgical complication. Immunological and non-immunological factors conditioning success of a second transplant are described in this volume, together with alternatives to retransplantation. It is hoped that, in the future, retransplants will be less frequent, as a result of improved prevention of transplant failure.
Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, wh...
Early in the 21st century, after the Great Recession, poet and young mother Maggie Roche is harassed by a lovely woman, Sriyanie, and a famous neuroscientist, David Elfield. She doesn't know it yet, but she is about to become history's first time traveler. When agents from the far future attempt to kill her, in baffled fury she slingshots herself into the 7th millennium. Instantly she's on the run from the Ull Lords and their virtual reality devotees. These superbeings are cyborged humans constructed to live forever, with the ambition to rule the universe. Maggie is having none of this. Encountering an earlier version of Sriyanie, her fated future role in the formation of the multiverse falls upon her shoulder like a thunderous lightningbolt. A Being at the end of time she calls the Something wages endless war with its foes, the Ull Lords. Torn from her beloved child and her own time, Maggie must choose whether to accept this alienating path into an alternative cosmic history fit for a poet and a free woman.
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A groundbreaking Virtual Reality textbook is now even better Virtual reality is a very powerful and compelling computer application by which humans can interface and interact with computer-generated environments in a way that mimics real life and engages all the senses. Although its most widely known application is in the entertainment industry, the real promise of virtual reality lies in such fields as medicine, engineering, oil exploration and the military, to name just a few. Through virtual reality scientists can triple the rate of oil discovery, pilots can dogfight numerically-superior "bandits," and surgeons can improve their skills on virtual (rather than real) patients. This Second E...
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This is a strong foundation of human-centric virtual reality design for anyone and everyone involved in creating VR experiences. Without a clear understanding of the human side of virtual reality (VR), the experience will always fail. The VR Book bridges this gap by focusing on human-centered design. Creating compelling VR applications is an incredibly complex challenge. When done well, these experiences can be brilliant and pleasurable, but when done badly, they can result in frustration and sickness. Whereas limitations of technology can cause bad VR execution, problems are oftentimes caused by a lack of understanding human perception, interaction, design principles, and real users. This b...
This book is about phylogenetic diversity as an approach to reduce biodiversity losses in this period of mass extinction. Chapters in the first section deal with questions such as the way we value phylogenetic diversity among other criteria for biodiversity conservation; the choice of measures; the loss of phylogenetic diversity with extinction; the importance of organisms that are deeply branched in the tree of life, and the role of relict species. The second section is composed by contributions exploring methodological aspects, such as how to deal with abundance, sampling effort, or conflicting trees in analysis of phylogenetic diversity. The last section is devoted to applications, showing how phylogenetic diversity can be integrated in systematic conservation planning, in EDGE and HEDGE evaluations. This wide coverage makes the book a reference for academics, policy makers and stakeholders dealing with biodiversity conservation.