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Treatment of Metastatic Melanoma
Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.
Melanoma
Melanoma - Current Clinical Management and Future Therapeutics serves as an advanced course in melanoma or an addendum to further polish expertise. Sections of the book include a thorough introduction on epidemiology and disease, the current surgical management of melanoma and lymph node dissection, immunotherapy along with drug toxicities and emerging research topics, like RAGE and autotaxin, that have potential therapeutic applications. The chapters in this book explore the most common subtype of melanoma, cutaneous disease, as well as a rare form, acral lentiginous melanoma and even canine tumors. Experts from around the globe contributed chapters, most of which have visual illustrations to depict aspects of disease management and therapy, allowing readers to grasp the advanced concepts presented.
Shakespeare, Tragedy and Menopause
Shakespeare was not only aware of the socio-cultural fears and anxieties generated by the older woman’s body but with the characterization of his tragic ageing females, Shakespeare becomes the first literary giant to explore the physiological and psychosocial condition that we have come to know as ‘menopause’. Although ‘menopause’ was not defined as a medical, physiological or sociocultural event for the early moderns, this book argues that such a medical and cultural transition can, in fact, be identified by sub-textual clues distinguished by various embodied anxieties. It explores several ageing women of the Shakespearean tragedies as they transition through this liminal menopausal period. Theoretically underscored by humoral theory, the analysis is metonymically centered upon the womb as the seat of menopausal anxiety. These menopausal undercurrents, not only permeate the dramatic action of each play, but also emanate outward to reflect the medical, physiological, cultural, social, and religious concerns generated by the ageing woman of the early modern period at large.
Prometheus Tamed
Over 8,200 large city fires broke out between 1000 and 1939 CE in Central Europe. Prometheus Tamed inquires into the long-term history of that fire ecology, its local and regional frequencies, its relationship to climate history. It asks for the visual and narrative representation of that threat in every-day life. Institutional forms of fire insurance emerged in the form of private joint stock companies (the British model, starting in 1681) or in the form of cameralist fire insurances (the German model, starting in 1676). They contributed to shape and change society, transforming old communities of charitable solidarity into risk communities, finally supplemented by networks of cosmopolite aid. After 1830, insurance agencies expanded tremendously quickly all over the globe: Cultural clashes of Western and native perceptions of fire risk and of what is insurance can be studied as part of a critical archaeology of world risk society and the plurality of modernities.
Dipeptidyl Aminopeptidases in Health and Disease
Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Human Papillomaviruses and Polyomaviruses in Skin Cancer
Nonmelanoma skin cancer (NMSC), more recently defined as keratinocyte carcinoma (KC), is the most frequent malignant tumor among Caucasians. This book deals with widely distributed cutaneous papillomaviruses and polyomaviruses, which are able to establish life-long persistent infections. They are frequently clinically inapparent in the general population, but can cause skin cancer in immunocompromised hosts or in the aging skin undergoing immunosenescence, thereby leading to major medical problems. The incidence of cutaneous squamous cell carcinoma (cSCC) in immunosuppressed organ transplant recipients is 60-250 times higher than that observed in the general population, which is highly sugge...
Recent Advances in the Biology, Therapy and Management of Melanoma
The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.
Dermatologic Surgery and Procedures
This book is intended for dermatologists, skin surgeons, and general practitioners who are interested in skin surgery and cosmetic procedures. The topics of broad and current interest in shaping the practice nowadays have been selected by the editor, Dr. Pierre Vereecken, MD, PhD, allowing the reader to expand his/her skills and surgical techniques. This book aims to meet the need for a practical guide to help the clinicians to extend their offer in daily practice in dermatology and corrective and skin cancer surgery.
Community Series in Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses, volume II
The ability to understand the underlying mechanisms that drive the heterogeneity in inflammatory responses among patients suffering from immune-mediated conditions is critical. The nature of the immune mechanism ranges from the degree of immune cell activation, to the HLA genotypes, and the intensity of responses of target tissues to cytokines. High throughput experiments have generated significant information for us to facilitate the identification of disease-associated components for different complex immune-mediated conditions (e.g. psoriasis, lupus, rheumatoid arthritis, inflammatory bowel diseases), and the advances in biotechnologies and efficiency in computational resources have furth...
