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Stem Cell Biology and Regenerative Medicine
The study of stem cell biology is under intensive investigation. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell and gene therapy. The aim of this book is to provide readers and researchers with timely and accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on conferences given by recognized scientists involved in the international master course on stem cell biology at Sorbonne Université in Paris.
The Stem Cell Microenvironment and Its Role in Regenerative Medicine and Cancer Pathogenesis
How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation. This ...
Marriage Alliance in Late Medieval Florence
Molho (European history, Brown U.) shows that the propertied families of late-medieval and early-modern Florence maintained their power and influence through arranged marriage and the dowry. While elsewhere in Europe the elite were toppling under the onslaught of commerce and personal freedom, in Florence they married carefully within a narrow and well-defined class, used dowries as both speculation and instruments of manipulation, and remembered every detail for a long time. Annotation copyright by Book News, Inc., Portland, OR
Stem Cell Engineering
The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
Stepwise Culture of Human Adult Stem Cells
This volume on stepwise techniques to culture adult human stem cells begins with the basic methods to culture adult stem cells followed by related methods to supplement stem cell culture. This and future volumes of techniques will allow laboratories across scientific entities – academic and commercial – to adapt the described methods for similar methods with cells from other species. The standardized techniques will allow across the board interpretation of other technologies such as Omics studies. These methods can be a starting platform for culturing stem cells even in laboratories that might not be familiar with the techniques. Scientific and early clinical trials strongly favor the development of translational studies with adult stem cells. A major impediment to progress in the field of regenerative medicine is a lack of standardized methods to culture specific stem cells. Such documented methods would allow for scientific rigor and reproducibility to enhance efficient and safe translation of stem cells to patients. This book fills that gap.
Basic Cardiovascular Physiology
This book focuses on established cardiovascular principles and highlights some of the progress achieved by recent research in the cardiovascular field. The authors report the basic concepts related to the functioning of the cardiovascular system necessary for medical students to understand. To foster learning, in each chapter the fundamental points are highlighted in italics and/or bold. In addition, we have added boxes that contain some more detailed information about physiological mechanisms or clinical aspects are analyzed and described in greater detail. The book describes the structure and function of the heart and vascular system for the reader to understand how the cardiovascular syst...
Brain Tumor and Nanotechnology
Brain Tumors and Nanotechnology explores the complex world of brain tumors and the ground-breaking role that nanotechnology is playing in both detection and treatment. It offers comprehensive and up-to-date strategies in the treatment of brain tumors, with a special emphasis on the revolutionary impact of nanotechnology. It begins with an in-depth analysis of the anatomy of the brain and nervous system, highlighting the constituents of the central nervous system (CNS) such as neurons and glial cells. It also offers a thorough understanding of the intricate structure of the human brain, including the hemispheres, brainstem, diencephalon, and ventricular system. It then reveals the understanding of the complicated nature of brain tumors and the potential for nanotechnology to revolutionize their diagnosis and treatment. Brain Tumors and Nanotechnology will be a longstanding valuable resource for researchers, medical professionals, and students in the field.
Myocardial Tissue Engineering
Myocardial tissue engineering (MTE), a concept that intends to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategi...
New Model of Burn Out Syndrome
This book is based on our most recent investigations revealing the complexity of the determinants of burn out in different populations at risk (health care professions, teachers, social workers etc.). Based on our empirical study we have developed a model of vulnerability to burn out which explains it as a specific complementary interaction between certain personality profile and the psychological climate at work place. In the course of evaluation there have been employed different inventories which are now validated as an assessment battery in about 300 subjects. Temperament and Character Inventory (revised) has been exclusively standardized for Bulgarian population as well Although burn ou...
