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Brain and Spinal Cord Atrophy in Multiple Sclerosis
Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.
Rome Is Burning
"Nero became Emperor in A.D 54. On the evening of July 18, 64 A. D., it seems that a lamp was left unextinguished in a stall still heaped with piles of combustible material. Whether this was accidental or deliberate we cannot now determine, and normally it would not have led to anything that would have attracted even local attention. But there was a gusty wind that night, and the flickering flame was fanned onto the flammable wares. The ensuing fire quickly spread. Before the onlookers could absorb what was happening one of the most catastrophic disasters ever to be endured by Rome was already underway. It was a disaster that brought death and misery to thousands. In Nero and the Great Fire ...
Vessel Health and Preservation: The Right Approach for Vascular Access
This Open access book offers updated and revised information on vessel health and preservation (VHP), a model concept first published in poster form in 2008 and in JVA in 2012, which has received a great deal of attention, especially in the US, UK and Australia. The book presents a model and a new way of thinking applied to vascular access and administration of intravenous treatment, and shows how establishing and maintaining a route of access to the bloodstream is essential for patients in acute care today. Until now, little thought has been given to an intentional process to guide selection, insertion and management of vascular access devices (VADs) and by default actions are based on cris...
Fanconi Anemia
Fanconi anemia (FA) is a rare genetic disease discovered 80 years ago by Guido Fanconi, an eminent Swiss pediatrician. It is characterized by short stature, skeletal anomalies, increased incidence of solid tumors and leukemias, bone marrow failure and cellular sensitivity to DNA damaging agents. Following a historical account, exemplary case reports and the current status of FA genes and their mutations, this volume discusses neoplasia in FA as well as current approaches to pre- and postnatal diagnosis. Further topics include revertant mosaicism as a kind of 'natural gene therapy' and hematopoietic stem cell transplantation as the only curative approach in FA. The final chapters investigate evolutionary aspects of the FA genes with special emphasis on the avian genome and the involvement of FA genes in recombinational types of DNA repair. Physicians and researchers in the fields of pediatrics, hematology, cancer, genetics, DNA repair and aging will benefit from understanding this disease, which illustrates the complex network of genomic maintenance systems that protect us from cancer and premature aging.
Comprehensive Medicinal Chemistry II, Volume 3
This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.
Emotions, Qualia, And Consciousness
The experience of emotion is a ubiquitous component of the stream of consciousness; emotional qualia interact with other contents and processes of consciousness in complex ways. Recent research has supported the hypothesis that important functional aspects of emotion can operate outside the conscious awareness. Primary types of emotions are found in animals, while secondary, more complex types are involved in interpersonal relationships. Emotions both influence genetic repair mechanisms of individuals and are responsible for group behavior. Many scholars and scientists believe that no scientific or philosophic account of consciousness can be complete without an understanding of the role of emotion.
Point-of-care testing
The underlying technology and the range of test parameters available are evolving rapidly. The primary advantage of POCT is the convenience of performing the test close to the patient and the speed at which test results can be obtained, compared to sending a sample to a laboratory and waiting for results to be returned. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis. Tests in a POC format can now be found for many medical disciplines including endocrinology/diabetes, cardiology, nephrolo...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
