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Gates reveals the guiding genius behind the unparalleled success of the Microsoft Corporation-- the biggest and most profitable personal computer software company in history-- and exposes the intensely competitive tactics that help it dominate the desktops of America. Chairman and co-founder of Microsoft, Bill Gates is the most powerful person in the computer industry and the youngest self-made billionaire in history. His company's DOS and Windows programs are such universal standards that more than nine out of ten personal computers depend on Microsoft software. Under the "Microsoft Everywhere" rallying cry, Gates intends to expand his company's worldwide dominance to office equipment, communications, and home entertainment. Vivid and definitive, Gates details the behind the scenes history of the personal computer industry and its movers and shakers, from Apple to IBM, from Steve Jobs to Ross Perot. Uncovering the inside stories of the bitter battle for control of the expanding personal computing market, Gates is a bracing, comprehensive portrait of the industry, the company, and the man-- and what they mean for a future where software is everything.
Learn To Play Electric Guitar is a truly unique method for the beginner guitarist, not only is this book a complete roadmap to learning the electric guitar but also included is special access to the books accompanying website. The accompanying website takes the method to the next level with each chapter having a video introduction and 95 play along tracks. It gives you the opportunity to get your questions answered by the authors themselves. The book is designed to take out the frustration and confusion when first learning the guitar giving beginners a solid foundation in electric guitar playing techniques such as: Power Chords 12 Bar Blues Improvisation Open Chords Barre Chords Minor Pentatonic Scale Lead Guitar Techniques
Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.
Data engineers who need to hit the ground running will use this book to build skills in Azure Data Factory v2 (ADF). The tutorial-first approach to ADF taken in this book gets you working from the first chapter, explaining key ideas naturally as you encounter them. From creating your first data factory to building complex, metadata-driven nested pipelines, the book guides you through essential concepts in Microsoft’s cloud-based ETL/ELT platform. It introduces components indispensable for the movement and transformation of data in the cloud. Then it demonstrates the tools necessary to orchestrate, monitor, and manage those components. This edition, updated for 2024, includes the latest dev...
Though celebrated at the peak of his career, Australian architect John Andrews' fame waned over time. His body of work exemplifies the late-modern development of architecture and deserves to be better known. John Andrews: Architect of Uncommon Sense examines his most important buildings and presents his local and international legacy.
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or ...
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The Andrews Sisters, the legendary singing trio of the 1930s, 1940s, and 1950s are the most successful female singing group in history and were the world's top selling group until the Beatles arrived. Of the 605 songs they recorded, 113 charted. They also made 18 movies, appeared regularly on radio and television, and entertained three generations of GIs. Based on extensive research, unpublished letters, and interviews with family, friends, and colleagues, this book documents not only the lives and work of the Andrews Sisters but also the popular culture spanned by their long careers. The book contains a complete discography of their released, unreleased, and solo recordings, including recording dates, record numbers, and accompaniment. Also included are a filmography and documentation of their radio and television appearances.
This handbook presents a series of essays that captures not the past of criminology, but where theoretical explanation is headed. The volume is replete with ideas, discussions of substantive topics with salient theoretical implications, and reviews of literatures that illuminate avenues along which theory and research evolve.