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Toxicology and Risk Assessment
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory...
Translational Recurrences
This book features 13 papers presented at the Fifth International Symposium on Recurrence Plots, held August 2013 in Chicago, IL. It examines recent applications and developments in recurrence plots and recurrence quantification analysis (RQA) with special emphasis on biological and cognitive systems and the analysis of coupled systems using cross-recurrence methods. Readers will discover new applications and insights into a range of systems provided by recurrence plot analysis and new theoretical and mathematical developments in recurrence plots. Recurrence plot based analysis is a powerful tool that operates on real-world complex systems that are nonlinear, non-stationary, noisy, of any statistical distribution, free of any particular model type and not particularly long. Quantitative analyses promote the detection of system state changes, synchronized dynamical regimes or classification of system states. The book will be of interest to an interdisciplinary audience of recurrence plot users and researchers interested in time series analysis of complex systems in general.
Assessing Nanoparticle Risks to Human Health
The book will take a systematic look at nanoparticle risks within the paradigm of risk assessment, consider the limitations of this paradigm in dealing with the extreme uncertainties regarding many aspects of nanoparticle exposure and toxicity, and suggest new methods for assessing and managing risks in this context. It will consider the occupational environment where the potential for human exposure is the greatest as well as the issues relevant to occupational exposure assessment (e.g., the exposure metric) and the evidence from toxicological and epidemiological studies. A chapter will be devoted to how conventional risk assessment can be carried out for a candidate nanoparticle (e.g., car...
Nanotechnology
The study tackles the subject in a new and unique way: Due to the fact that the borders between classical academic disciplines disappear at the nanoscale, a truly interdisciplinary approach is chosen. A functional definition of nanotechnology is developed by the authors as basis for the further sections of the study. The most important results enable recommendations with respect to scientific progress, industrial relevance, economic potential, educational needs, potential adverse health effects and philosophical aspects of nanotechnology. The book addresses the relevant decision levels, media, and academia.
Nanoarchitectonics for Brain Drug Delivery
This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoreti...
Oxygen/Nitrogen Radicals: Cell Injury and Disease
A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.
Nanomaterials
Production of nanomaterials has been constantly evolving over the last few years for manifold applications in electronic, optical and biomedical fields. As a result, exposure towards nanoparticles in the workplace environment is increasing, while respective occupational exposure limits are lacking. The Deutsche Forschungsgemeinschaft's Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) recognized the importance of a scientifically based approach to the risk assessment of nanoparticles at the workplace and in 2009 established the ad-hoc working group ?Nanoparticles'. Its task was to review the current database available for risk assessment for nanoparticles, to identify relevant endpoints of toxicological concern and to define open questions for future research. This report contains overviews on the important toxicological aspects of the nanoparticles and a summary and conclusions of the discussions that took place during the meetings of the ad hoc working group ?Nanoparticles'.
Nanocosmetics
This book offers an overview of the science of cosmetics and the formulation of nanosized cosmetic products including fabrication, characterization of nanocosmetics, major challenges in the safe applications, regulatory aspects, and commercialization on a large scale. The chapters provide understanding of the interaction of nanocarriers with skin and hair, different nanocosmetic products in the present situation, applications as well as disadvantageous toxicity associated with nanocosmetics, regulatory prospects, and future perspectives. Features: Provide an explicit account on vital aspects of various nanocosmetics drug delivery approaches, thereby providing a next-generation cosmetic produ...
Drug Delivery Using Nanomaterials
After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful a...
Nano Semiconducting Materials
Due to their unique optical, thermal, catalytic, magnetic and electronic properties, nano-sized semiconductors have a huge potential in a great number of technological applications, ranging from photovoltaics and photocatalysis to biosensors and medicine. In the last couple of decades, the synthesis and characterization of these materials has been of key interest not only to materials scientists but also to researchers working in the field of physics, chemistry, molecular biology and medicine. The main focus of the present book is the characterization of a number of nano-semiconducting materials, using such techniques as powder X-ray diffraction, UV-visible spectrophotometry, Raman spectrome...
