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Radiation-induced lymphopenia (RIL) is a long-known and frequent toxicity of radiotherapy and is the direct consequence of cell death of lymphocytes crossing the radiation field during treatment. In recent years, interest and evidence have been growing for the negative influence of RIL on treatment outcomes and survival of patients with solid tumors. Especially since the rise of immunotherapy, which is largely reliant on vital lymphocytes. Insight into clinical and dosimetric risk factors can help identify patients with an increased risk of RIL and possible management. Methods to mitigate RIL aim to reduce unintentional exposure of the circulating blood pool and secondary lymphoid organs to radiotherapy, with the ultimate goal of improving survival.
This book constitutes the refereed proceedings of the 16th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2010, held in Paphos, Cyprus, in March 2010, as part of ETAPS 2010, the European Joint Conferences on Theory and Practice of Software. The 35 papers presented were carefully reviewed and selected from 134 submissions. The topics covered are probabilistic systems and optimization, decision procedures, tools, automata theory, liveness, software verification, real time and information flow, and testing.
Offers a broad and vivid overview of the culture of collecting in France over the long nineteenth-century.
On Diary is the second collection in English of the groundbreaking and profoundly influential work of one of the best-known and provocative theorists of autobiography and diary. Ranging from the diary’s historical origins to its pervasive presence on the Internet, from the spiritual journey of the sixteenth century to the diary of Anne Frank, and from the materials and methods of diary writing to the question of how diaries end, these essays display Philippe Lejeune’s expertise, eloquence, passion, and humor as a commentator on the functions, practices, and significance of keeping or reading a diary. Lejeune is a leading European critic and theorist of diary and autobiography. His landma...
Surgical robotics is a rapidly evolving field. With roots in academic research, surgical robotic systems are now clinically used across a wide spectrum of surgical procedures. Surgical Robotics: Systems Applications and Visions provides a comprehensive view of the field both from the research and clinical perspectives. This volume takes a look at surgical robotics from four different perspectives, addressing vision, systems, engineering development and clinical applications of these technologies. The book also: -Discusses specific surgical applications of robotics that have already been deployed in operating rooms -Covers specific engineering breakthroughs that have occurred in surgical robotics -Details surgical robotic applications in specific disciplines of surgery including orthopedics, urology, cardiac surgery, neurosurgery, ophthalmology, pediatric surgery and general surgery Surgical Robotics: Systems Applications and Visions is an ideal volume for researchers and engineers working in biomedical engineering.
From beloved author Alyson Gerber comes another realistic contemporary novel perfect for fans of Judy Blume. Sarah loves basketball more than anything. Crushing it on the court makes her feel like she matters. And it's the only thing that helps her ignore how much it hurts when her mom forgets to feed her. But lately Sarah can't even play basketball right. She's slower now and missing shots she should be able to make. Her body doesn't feel like it's her own anymore. She's worried that changing herself back to how she used to be is the only way she can take control over what's happening. When Sarah's crush asks her to be partners in a cooking competition, she feels pulled in a million directions. She'll have to dig deep to stand up for what she needs at home, be honest with her best friends, and accept that she doesn't need to change to feel good about herself. Booklist described Gerber's novels in starred reviews as both "highly empathetic" and "truly inspiring." Taking Up Space promises to be a realistic and compelling story about struggling with body image and learning that true self-esteem comes from within.
The articles collected in this volume from the two companion Arts Special Issues, "The Machine as Art (in the 20th Century)" and "The Machine as Artist (in the 21st Century)", represent a unique scholarly resource: analyses by artists, scientists, and engineers, as well as art historians, covering not only the current (and astounding) rapprochement between art and technology but also the vital post-World War II period that has led up to it; this collection is also distinguished by several of the contributors being prominent individuals within their own fields, or as artists who have actually participated in the still unfolding events with which it is concerned
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Constraint programming is a powerful paradigm for solving combinatorial search problems that draws on a wide range of techniques from artificial intelligence, computer science, databases, programming languages, and operations research. Constraint programming is currently applied with success to many domains, such as scheduling, planning, vehicle routing, configuration, networks, and bioinformatics.The aim of this handbook is to capture the full breadth and depth of the constraint programming field and to be encyclopedic in its scope and coverage. While there are several excellent books on constraint programming, such books necessarily focus on the main notions and techniques and cannot cover...
One woman learns that the price of belonging is often steeper than expected in this heart-wrenching yet hopeful romantic novel and first in the Seoul duology by USA Today bestselling author Jen Frederick. As a Korean adoptee, Hara Wilson doesn’t need anyone telling her she looks different from her white parents. She knows. Every time Hara looks in the mirror, she’s reminded that she doesn’t look like anyone else in her family—not her loving mother, Ellen; not her jerk of a father, Pat; and certainly not like Pat’s new wife and new “real” son. At the age of twenty-five, she thought she had come to terms with it all, but when her father suddenly dies, an offhand comment at his fu...