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The Cox Model and Its Applications
This book will be of interest to readers active in the fields of survival analysis, genetics, ecology, biology, demography, reliability and quality control. Since Sir David Cox’s pioneering work in 1972, the proportional hazards model has become the most important model in survival analysis. The success of the Cox model stimulated further studies in semiparametric and nonparametric theories, counting process models, study designs in epidemiology, and the development of many other regression models that could offer more flexible or more suitable approaches in data analysis. Flexible semiparametric regression models are increasingly being used to relate lifetime distributions to time-dependent explanatory variables. Throughout the book, various recent statistical models are developed in close connection with specific data from experimental studies in clinical trials or from observational studies.
Regression Modeling Strategies
Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".
An R and S-Plus Companion to Applied Regression
"This book fits right into a needed niche: rigorous enough to give full explanation of the power of the S language, yet accessible enough to assign to social science graduate students without fear of intimidation. It is a tremendous balance of applied statistical "firepower" and thoughtful explanation. It meets all of the important mechanical needs: each example is given in detail, code and data are freely available, and the nuances of models are given rather than just the bare essentials. It also meets some important theoretical needs: linear models, categorical data analysis, an introduction to applying GLMs, a discussion of model diagnostics, and useful instructions on writing customized functions. " —JEFF GILL, University of Florida, Gainesville
Biostatistical Applications in Cancer Research
Biostatistics is defined as much by its application as it is by theory. This book provides an introduction to biostatistical applications in modern cancer research that is both accessible and valuable to the cancer biostatistician or to the cancer researcher, learning biostatistics. The topical areas include active areas of the application of biostatistics to modern cancer research: survival analysis, screening, diagnostics, spatial analysis and the analysis of microarray data. Biostatistics is an essential component of basic and clinical cancer research. The text, authored by distinguished figures in the field, addresses clinical issues in statistical analysis. The spectrum of topics discussed ranges from fundamental methodology to clinical and translational applications.
Progress in Radiopharmacy
The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was held in St. Catharine's College Cambridge in March 1985. This meeting was organized by the Radiopharmacy Group of the British Nuclear Medicine Society under the auspices of the European Joint Committee on Radio pharmaceuticals of the ENMS / SNME. The Joint Committee acknowledges the special effort which was made by the local organizers to prepare this meeting the quality of which is undoubtedly reflected in the proceedings. The wide ranging aspects of Radiopharmacy are reflected in this volume which not only deals with specialized topics, such as ...
Cholescintigraphy
This book is timely and fills a void in the area of cholescintigraphy in Nuclear Medicine. It is true that many articles and papers from symposia on this subject are available but they are all scattered through a volumnous literature. Dr Cox and his colleagues have brought together in an orderly fashion the current available material on hepatobiliary scintigraphy in an excellent volume suitable for both the clinician as well as the clinical scientist. This volume begins with a detailed discussion of anatomy and physiological functions of the liver and bi liary tract followed by a section on scintigraphic functional imaging of the liver. A description of the chemistry and pharma 99m ceutical ...
Nuclear Medicine in Gastroenterology
During the last two decades significant advances have been made in the in vivo-diagnosis of gastrointestinal diseases. Although Ultrasound and CT as well as Endoscopy have had a major impact on the evaluation of liver, pancreas and bile diseases, there are a lot of indications for Nuclear Medicine procedures. These include new investigational procedures like esophageal scintigraphy, proof of bleeding sites, scintigraphy of inflammatory diseases, and intestinal resorption tests. Further, immunoscintigraphy with radiol- elled antibodies has gained wide-spread application especially in colon cancer. The differential diagnosis of liver tumors like haemangioma and focal nodular hyperplasia by mea...
The Clinical Applications of SPET
In the past nuclear medicine has tended to develop in cycles governed by the development of new radiopharmaceuticals followed or preceded by advances in instrumentation. The development of alternative techniques, such as X-Ray Computer Tomography, NMR Imaging and Ultrasound have also had a stimulating effect and pointed the way to new developments. The development of Positron Emission Tomography, while in itself of limited application because of high costs involved, provided a great deal of information which led to the development of new organ or disease specific, single photon emitting radiopharmaceuticals together with tomographic Gamma cameras, whereby detailed information on the biodistr...
Radiopharmacy and Radiopharmacology
First Published in 1985. Routledge is an imprint of Taylor & Francis, an informa company.
Progress in Radiopharmacology 1985
This volume is based upon presentations made to the 4th European Symposium on Radiopharmacology which was held under the auspices of the European Joint Committee on Radiopharma ceuticals (ENMS / SNME) in Athens from March 28 - 31, 1984. The Medical Insurance Foundation of the National Bank of Greece (TYPET) sponsored this meeting and the Joint Committee would like to express their gratitude to the local organising committee: G. Limouris, M. Pierroutsakou, A. Sarris, A. Tzoulis and C. Binas. A word of thanks also to Mrs. Tineke Busker who prepared the camera ready copy. The meeting reflects the continuing and growing interest in biodistribution and factors which can influence bio distribution...
