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This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods
In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.
This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. - Expert authors who are leaders in the field - Extensively referenced and useful figures and tables - Provides hints and tricks to facilitate reproduction of methods
Despite the substantial efforts made to prevent the disease by early detection, cervical cancer remains a leading cause of mortality among women worldwide. The European Research Organization on Genital Infection and Neoplasia (EUROGIN) pursues a wide variety of educational and training activities, aiming to spread accurate and state-of-the-art information in the field of cervical cancer prevention. The latest outcome of these activities is presented in this book. Providing a concise update of the current knowledge on human papillomavirus (HPV) infections and their intimate link to cervical cancer, the book focuses on five interrelated topics: high- and low-risk HPV infections, methods for HPV detection and use of molecular markers, HPV testing in primary screening and patient management, morphological diagnosis and treatment, as well as prevention of cervical cancer by vaccines. Written by leading international experts, this publication is targeted at a multidisciplinary readership consisting of health care professionals from diverse specialties engaged in the management of HPV-associated diseases.
Current placental research in Japan, reflecting the adoption of recent biochemical, immunochemical and microbiological knowledge and techniques, and the resulting observation of enzyme activity and transportation of a variety of substances utilising isolated BBM, BBMV, BM and BMV. Also Vol. 10: Early PregnancyCovering: Trophoblast invasion . Angiogenesis and Blood Vessels . Endocrine and Paracine Regulation. With the European Placenta Group
This book constitutes the refereed proceedings of the 18th Australian Joint Conference on Artificial Intelligence, AI 2005, held in Sydney, Australia in December 2005. The 77 revised full papers and 119 revised short papers presented together with the abstracts of 3 keynote speeches were carefully reviewed and selected from 535 submissions. The papers are catgorized in three broad sections, namely: AI foundations and technologies, computational intelligence, and AI in specialized domains. Particular topics addressed by the papers are logic and reasoning, machine learning, game theory, robotic technology, data mining, neural networks, fuzzy theory and algorithms, evolutionary computing, Web intelligence, decision making, pattern recognition, agent technology, and AI applications.
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No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
In the late 1980s, a national outcry followed the publication of Sandra Coney and Phillida Bunkle's 'Unfortunate Experiment' article in Metro magazine about the treatment of carcinoma in situ at National Women's Hospital. The article prompted a commission of inquiry led by Judge Silvia Cartwright which indicted the practices of doctors at the hospital and led to lawsuits, censure, a national screening programme and a revolution in doctor-patient relations in New Zealand. In this carefully researched book, medical historian Dr Linda Bryder provides a detailed analysis of the treatment of carcinoma in situ at National Women's since the 1950s, an assessment of international medical practice and a history of the women's health movement. She tackles a number of key questions. Was treatment at National Women's an 'unfortunate experiment'? Was it out of line with international norms? Did Herb Green and his colleagues care more for science than for their patients? Did women die as a result? And what were the sources of the scandal that erupted?
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