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Thyroid Autoimmunity
In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an Internati...
Chorionic Gonadotropin
This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.
The Garden
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Autoimmune Thyroiditis
Current knowledge relevant to the understanding of thyroid autoimmunity is summarized in this book. Some of the world's leading scientists in this field review recent data from four subject areas: immunogenetics, thyroid peroxidase as an antigen, environmental factors, and cytokines. Much ongoing and as yet unpublished work is described, especially in the discussion included after each article. This information is of particular interest since the body of knowledge in these fields is growing very rapidly. The book is based on a workshop in which researchers from 13 countries took part. One major aim was to raise controversial points and to develop ideas for their potential solution. At the workshop it became apparent that a great deal of the information given in textbooks is outdated. This is an important update for researchers who are interested in the above topics and in understanding the etiology and pathogenesis of thyroid autoimmunity.
The Papers of Benjamin Franklin
In the four months following the January 20, 1783, armistice that ended the War for American Independence, Franklin was remarkably energetic as he helped oversee the transition to peace and waged a multifaceted campaign to publicize the ideals of the new nation. Though political turmoil in Britain delayed negotiations for the definitive peace treaty, Franklin deftly negotiated America's first commercial treaty with a neutral nation, Sweden, which was signed in secret. He distributed his richly symbolic Libertas Americana medal, worked toward the publication of his French edition of the American state constitutions, and fielded scores of letters from people all over Europe who sought to emigrate, to establish trade connections with the United States, to become consuls, and to offer congratulations and advice.
La splendeur des dieux: Quatre études iconographiques sur l’hellénisme égyptien (2 vols)
Que viennent faire les rayons solaires du dieu grec Hélios sur le front d’un dieu crocodile égyptien ? Cette question est au point de départ d’une enquête au cœur de la plasticité du système polythéiste de l’Égypte gréco-romaine. Parcourant le labyrinthe des diverses communautés et croyances grecques et égyptiennes, Gaëlle Tallet utilise le fil d’Ariane de la production des images religieuses, réponses à de nouveaux besoins et de nouvelles perceptions du divin, et ouvre les portes des ateliers où elles ont été conçues, commandées et façonnées. La Splendeur des dieux propose une réévaluation du rôle des clergés et des artistes indigènes dans l’élaboration...
National Library of Medicine Current Catalog
First multi-year cumulation covers six years: 1965-70.
RT-PCR Protocols
Until the mid 1980s, the detection and quantification of a specific mRNA was a difficult task, usually only undertaken by a skilled molecular biologist. With the advent of PCR, it became possible to amplify specific mRNA, after first converting the mRNA to cDNA via reverse transcriptase. The arrival of this technique—termed reverse transcription-PCR (RT-PCR)—meant that mRNA suddenly became amenable to rapid and sensitive analysis, without the need for advanced training in molecular biology. This new accessibility of mRNA, which has been facilitated by the rapid accumulation of sequence data for human mRNAs, means that every biomedical researcher can now include measurement of specific mR...
