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LC-MS in Drug Bioanalysis
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Ultra-High Performance Liquid Chromatography and Its Applications
Explores both the benefits and limitations of new UHPLC technology High performance liquid chromatography (HPLC) has been widely used in analytical chemistry and biochemistry to separate, identify, and quantify compounds for decades. The science of liquid chromatography, however, was revolutionized a few years ago with the advent of ultra-high performance liquid chromatography (UHPLC), which made it possible for researchers to analyze sample compounds with greater speed, resolution, and sensitivity. Ultra-High Performance Liquid Chromatography and Its Applications enables readers to maximize the performance of UHPLC as well as develop UHPLC methods tailored to their particular research needs...
Analytical Methods for Therapeutic Drug Monitoring and Toxicology
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Mathematical Reviews
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Strangers on the Western Front
During World War I, Britain and France imported workers from their colonies to labor behind the front lines. The single largest group of support labor came not from imperial colonies, however, but from China. Xu Guoqi tells the remarkable story of the 140,000 Chinese men recruited for the Allied war effort. These laborers, mostly illiterate peasants from north China, came voluntarily and worked in Europe longer than any other group. Xu explores China’s reasons for sending its citizens to help the British and French (and, later, the Americans), the backgrounds of the workers, their difficult transit to Europe—across the Pacific, through Canada, and over the Atlantic—and their experience...
Student Directory
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System Design Interview - An Insider's Guide
The system design interview is considered to be the most complex and most difficult technical job interview by many. Those questions are intimidating, but don't worry. It's just that nobody has taken the time to prepare you systematically. We take the time. We go slow. We draw lots of diagrams and use lots of examples. You'll learn step-by-step, one question at a time.Don't miss out.What's inside?- An insider's take on what interviewers really look for and why.- A 4-step framework for solving any system design interview question.- 16 real system design interview questions with detailed solutions.- 188 diagrams to visually explain how different systems work.
Optics Letters
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Olympic Dreams
Already the world has seen the political, economic, and cultural significance of hosting the 2008 Olympics in Beijing—in policies instituted and altered, positions softened, projects undertaken. But will the Olympics make a lasting difference? This book approaches questions about the nature and future of China through the lens of sports—particularly as sports finds its utmost international expression in the Olympics.
