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LC-MS in Drug Bioanalysis
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Comprehensive Organic Synthesis
The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic sy...
Philosophy of Chemistry
This volume follows the successful book, which has helped to introduce and spread the Philosophy of Chemistry to a wider audience of philosophers, historians, science educators as well as chemists, physicists and biologists. The introduction summarizes the way in which the field has developed in the ten years since the previous volume was conceived and introduces several new authors who did not contribute to the first edition. The editors are well placed to assemble this book, as they are the editor in chief and deputy editors of the leading academic journal in the field, Foundations of Chemistry. The philosophy of chemistry remains a somewhat neglected field, unlike the philosophy of physic...
Strangers on the Western Front
During World War I, Britain and France imported workers from their colonies to labor behind the front lines. The single largest group of support labor came not from imperial colonies, however, but from China. Xu Guoqi tells the remarkable story of the 140,000 Chinese men recruited for the Allied war effort. These laborers, mostly illiterate peasants from north China, came voluntarily and worked in Europe longer than any other group. Xu explores China’s reasons for sending its citizens to help the British and French (and, later, the Americans), the backgrounds of the workers, their difficult transit to Europe—across the Pacific, through Canada, and over the Atlantic—and their experience...
Simple Games
Simple games are mathematical structures inspired by voting systems in which a single alternative, such as a bill, is pitted against the status quo. The first in-depth mathematical study of the subject as a coherent subfield of finite combinatorics--one with its own organized body of techniques and results--this book blends new theorems with some of the striking results from threshold logic, making all of it accessible to game theorists. Introductory material receives a fresh treatment, with an emphasis on Boolean subgames and the Rudin-Keisler order as unifying concepts. Advanced material focuses on the surprisingly wide variety of properties related to the weightedness of a game. A desirab...
Olympic Dreams
Already the world has seen the political, economic, and cultural significance of hosting the 2008 Olympics in Beijing—in policies instituted and altered, positions softened, projects undertaken. But will the Olympics make a lasting difference? This book approaches questions about the nature and future of China through the lens of sports—particularly as sports finds its utmost international expression in the Olympics.
LC-MS in Drug Bioanalysis
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Maximum Likelihood Estimation for Sample Surveys
Sample surveys provide data used by researchers in a large range of disciplines to analyze important relationships using well-established and widely used likelihood methods. The methods used to select samples often result in the sample differing in important ways from the target population and standard application of likelihood methods can lead to biased and inefficient estimates. Maximum Likelihood Estimation for Sample Surveys presents an overview of likelihood methods for the analysis of sample survey data that account for the selection methods used, and includes all necessary background material on likelihood inference. It covers a range of data types, including multilevel data, and is i...
System Design Interview - An Insider's Guide
The system design interview is considered to be the most complex and most difficult technical job interview by many. Those questions are intimidating, but don't worry. It's just that nobody has taken the time to prepare you systematically. We take the time. We go slow. We draw lots of diagrams and use lots of examples. You'll learn step-by-step, one question at a time.Don't miss out.What's inside?- An insider's take on what interviewers really look for and why.- A 4-step framework for solving any system design interview question.- 16 real system design interview questions with detailed solutions.- 188 diagrams to visually explain how different systems work.
Chinese and Americans
Chinese–American relations are often viewed through the prism of power rivalry and civilization clash. But China and America’s shared history is much more than a catalog of conflicts. Using culture rather than politics or economics as a reference point, Xu Guoqi highlights significant yet neglected cultural exchanges in which China and America have contributed to each other’s national development, building the foundation of what Zhou Enlai called a relationship of “equality and mutual benefit.” Xu begins with the story of Anson Burlingame, Abraham Lincoln’s ambassador to China, and the 120 Chinese students he played a crucial role in bringing to America, inaugurating a program of...
