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Treatment of Multiple Myeloma and Related Disorders
Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.
Neoplastic Diseases of the Blood
In this fourth edition of the classic work on malignant blood cancers, the team of editors and over 100 international leaders in the field provide a comprehensive text on the diagnosis and treatment of all hematologic malignancies, both common and rare. The sixty-two chapters are divided into sections on Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, Lymphomas, and Supportive Care, with a devoted editor for each section. This extensively revised and updated edition reflects the tremendous progress in the science and treatment of hematologic malignancies during the eight years since the third edition in 1995. Revisions and new chapters include coverage of stem cell transplantation, molecular genetics, monoclonal antibodies, and new treatment modalities. The excellent discussions of current therapies for all hematologic neoplasms are more detailed than those in general oncology or hematology texts, making this an essential reference for all hematologists and oncologists.
Novel Anticancer Drug Protocols
We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.
The Baltic and the Outbreak of the Second World War
This book is the first to highlight the importance of the Baltic region in the approach to war in 1939. Amid the welter of publications on the origins of the Second World War none has sought hitherto to focus on the Baltic region, where peace finally and irrevocably broke down. Central strategic and international issues of the interwar years are thus illuminated from a fresh perspective by a distinguished team of specialists that includes a number of native Baltic historians. The themes discussed by the contributors acquired renewed relevance, as the Baltic republics asserted their rejection of incorporation within the Soviet Union following the Nazi-Soviet pact of 1939. The Baltic and the outbreak of the Second World War makes an important contribution to the perennial debate on the immediate causes of the conflict, and should interest specialists in a variety of fields within international relations, modern European and diplomatic history.
Camille Gutt and Postwar International Finance
As a businessman, financier, diplomat, minister, and first Managing Director of the IMF, Camille Gutt (1884–1971) was involved in all the important financial negotiations between the 1920s and the 1950s. Using Gutt’s personal archives as his starting point, Crombois examines the rise and fall of financial diplomacy as a largely private enterprise.
Germans to the Front
In Germans to the Front, David Large charts the path from Germany's total demilitarization immediately after World War II to the appearance of the Bundeswehr, the West German army, in 1956. The book is the first comprehensive study in English of West German rearmament during this critical period. Large's analysis of the complex interplay between the diplomatic and domestic facets of the rearmament debate illuminates key elements in the development of the Cold War and in Germany's ongoing difficulty in formulating a role for itself on the international scene. Rearmament severely tested West Germany's new parliamentary institutions, dramatically defined emerging power relationships in German politics, and posed a crucial challenge for the NATO alliance. Although the establishment of the Bundeswehr ultimately helped stabilize the nation, the acrimony surrounding its formation generated deep divisions in German society that persisted long after the army took the field. According to Large, the conflict was so bitter because rearmament forced a confrontation with fundamental questions of national identity and demanded a painful reckoning with the past.
Hematopathology in Oncology
- Provides the reader with insight into the emerging roles of the pathologist and clinical labortory - This volume includes all the latest concepts in the field
Diagnostic and Therapeutic Advances in Hematologic Malignancies
There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constantly evolving concepts in this area.
